Effect of acute and chronic morphine administration on brain cholinergic muscarinic receptors.
Effect of acute and chronic morphine administration on brain cholinergic muscarinic receptors.
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急性和慢性吗啡给药对脑胆碱能毒蕈碱受体的影响。
DOI：
10.1016/0306-3623(86)90135-7
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Bhargava,HN
中科院分区：
文献类型：
--
作者：
Das,S;Matwyshyn,GA;Bhargava,HN
在急性或慢性吗啡处理的大鼠中，测定了[~ 3 H]奎宁环基二苯甲酸酯（QNB）与不同脑区的结合。吗啡和纳洛酮，在体外，抑制结合[3 H] QNB纹状体膜只有在高浓度。单次注射后30分钟，吗啡（5或40 mg/kg sc）没有改变[3 H] QNB与纹状体受体结合的Bmax或Kd值。在吗啡耐受依赖大鼠和突然戒断或纳洛酮催促戒断大鼠中，[~ 3 H] QNB与不同脑区膜的结合没有改变。结果表明，中枢胆碱能毒蕈碱受体不受急性或慢性吗啡治疗，或在禁欲。
The binding of [3H] quinuclidinyl benzilate (QNB) to various brain regions was determined in rats after acute or chronic treatment with morphine. Morphine and naloxone, in vitro, inhibited the binding of [3H] QNB to striatal membranes only at high concentrations. Thirty minutes after a single injection, morphine (5 or 40 mg/kg sc) did not alter the Bmax or Kd values for [3H] QNB binding to striatal receptors. The binding of [3H] QNB to membranes of different brain regions was not changed in morphine tolerant-dependent rats or rats undergoing abrupt or naloxone precipitated withdrawal. The results suggest that central cholinergic muscarinic receptors are unaffected by acute or chronic treatment with morphine, or during abstinence.