Nanomedicine for Treatment of Lung Cancer
Nanomedicine for Treatment of Lung Cancer
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DOI：
10.1007/978-3-319-24932-2_8
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Hussain, Sajid
中科院分区：
文献类型：
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作者：
Hussain, Sajid
肺癌是第二大常见癌症，也是美国和世界其他地区男性和女性癌症相关死亡的主要原因。由于在晚期诊断，它与大多数患者的高死亡率相关。近年来，纳米技术在癌症检测、诊断和治疗中的开发和应用取得了巨大进展。这一进展推动了“癌症纳米医学”新兴领域的发展。“基于纳米颗粒的治疗系统由于其生物利用度、体内稳定性、肠道吸收、溶解性、持续和靶向递送以及几种抗癌剂的治疗效果而获得了极大的普及。目前，使用了过多的纳米载体制剂，包括基于脂质的、聚合的和支化的聚合的、基于金属的、磁性的和中孔二氧化硅。在肺癌中，基于纳米颗粒的治疗方法为原发性和转移性肿瘤的诊断、成像、筛查和治疗铺平了道路。用于药物递送的新型纳米载体的应用和扩展是一个令人兴奋和具有挑战性的研究领域，特别是对于新兴癌症治疗的递送。本文讨论了目前基于纳米颗粒的肺癌治疗药物传递系统的一些进展和挑战。
Lung cancer is the second most common cancer and the primary cause of cancer-related death in both men and women in the United States and rest of the world. Due to diagnosis at an advanced stage, it is associated with a high mortality in a majority of patients. In recent years, enormous advances have occurred in the development and application of nanotechnology in the detection, diagnosis, and therapy of cancer. This progress has led to the development of the emerging field of "cancer nanomedicine." Nanoparticle-based therapeutic systems have gained immense popularity due to their bioavailability, in vivo stability, intestinal absorption, solubility, sustained and targeted delivery, and therapeutic effectiveness of several anticancer agents. Currently, a plethora of nanocarrier formulations are utilized including lipid-based, polymeric and branched polymeric, metal-based, magnetic, and mesoporous silica. In lung cancer, nanoparticle-based therapeutics is paving the way in the diagnosis, imaging, screening, and treatment of primary and metastatic tumors. The application and expansion of novel nanocarriers for drug delivery is an exciting and challenging research filed, in particular for the delivery of emerging cancer therapies. Some of the current progress and challenges in nanoparticle-based drug delivery systems for lung cancer treatment are discussed.