Two-Dimensional MXene-Originated In Situ Nanosonosensitizer Generation for Augmented and Synergistic Sonodynamic Tumor Nanotherapy
Two-Dimensional MXene-Originated In Situ Nanosonosensitizer Generation for Augmented and Synergistic Sonodynamic Tumor Nanotherapy
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源自二维 MXene 的原位纳米声敏剂生成，用于增强和协同声动力肿瘤纳米治疗
DOI：
10.1021/acsnano.2c04630
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Xiangxiang Jing
中科院分区：
文献类型：
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作者：
Min Zhang;Dayan Yang;Caihong Dong;Hui Huang;Guiying Feng;Qiqing Chen;Yuanyi Zheng;Hailin Tang;Yu Chen;Xiangxiang Jing
Despite the merits of high tissue-penetrating depth, no ionizing radiation, and low cost, sonodynamic therapy (SDT) still suffers from a low quantum yield of reactive oxygen species (ROS), limited delivery efficiency, and potential toxicity of sonosensitizers. Different from the direct delivery of sonosensitizers into tumor tissue for SDT, this work reports the fabrication of two-dimensional (2D) nanosonosensitizers/nanocatalysts (Ti3C2/CuO2@BSA) for thein situgeneration of nanosonosensitizers by responding to the tumor microenvironment, achieving the high-performance and synergistic sonodynamic/chemodynamic tumor therapy. CuO2nanoparticle integration on 2D Ti3C2MXene achievedin situH2O2generation in an acidic tumor microenvironment for oxidizing Ti3C2to produce TiO2nanosonosensitizers, accompanied by the enhanced separation of electrons (e–) and holes (h+) by the carbon matrix after oxidation, further augmenting the SDT efficacy. Ultrasound irradiation during the sonodynamic process also enhanced the Cu-initiated Fenton-like reaction to produce more ROS for synergizing the sonodynamic tumor therapy. The experimental results confirm and demonstrate the synergistic therapeutic effects of chemodynamic and sonodynamic nanotherapy bothin vitroandin vivo. The antitumor mechanisms of synergistic chemodynamic and sonodynamic therapies are associated with the upregulation of oxidative phosphorylation, ROS generation, and apoptosis as demonstrated by RNA sequencing. This work thus provides a distinct paradigm of 2D MXene-originatedin situnanosonosensitizer generation for augmented and synergistic sonodynamic tumor nanotherapy.
