Gene-environment association of an ITGB2 sequence variant with obesity in ethnic Japanese
Gene-environment association of an ITGB2 sequence variant with obesity in ethnic Japanese
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DOI：
10.1038/oby.2008.68
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发表时间：
2008-06-01
期刊：
影响因子：
6.9
通讯作者：
Eboshida, Akira
中科院分区：
文献类型：
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作者：
Awaya, Tomokazu;Yokosaki, Yasuyuki;Eboshida, Akira
缺乏整合素- M - 2 （Mac-1, CD11b/CD18）的小鼠在富含脂肪的西方饮食中出现肥胖表型。然而，目前还没有发现编码整合素M β 2的人类基因变异与肥胖之间的联系。本研究旨在探讨编码人类整合素β 2亚基（ITGB2）基因的单核苷酸多态性（rs235326）与肥胖之间的关系。我们的受试者队列包括651名日裔，其中274人是居住在夏威夷的日裔美国人，其余377人是日本本地人，这两个群体具有相同的遗传背景，有或没有西化的生活方式。我们使用taqMan试验对rs235326多态性进行了基因分型。在日裔美国人群中，使用隐性模型和经年龄调整的逻辑回归分析，发现TT纯合子的肥胖风险比C携带者高3.29倍（95%可信区间为1.25-8.67,P = 0.02）。这种关联在日本本土个体中没有发现。这些结果表明，ITGB2基因的rs235326多态性与生活在美国的日本人的肥胖有关，他们的饮食已经“西方化”。
Mice lacking the integrin alpha M beta 2 ( Mac-1, CD11b/CD18) develop an obese phenotype on western diet rich in fat. However, no association has been found between variations in the human genes encoding the integrin alpha M beta 2 and obesity. this study was aimed to investigate the association between a single-nucleotide polymorphism (sNP) ( rs235326) in the gene encoding human integrin beta 2 subunit (ITGB2) with obesity. our subject cohort comprised 651 people of Japanese ethnicity, of which 274 were Japanese Americans living in Hawaii, and the remaining 377 were native Japanese, two populations in the same genetic background with or without westernized life style. We genotyped the rs235326 polymorphism using a taqMan assay. in the Japanese-American population, the risk of obesity was found to be 3.29-fold higher ( a 95% confidence interval of 1.25-8.67, P = 0.02) in TT homozygotes than in C carriers, using a recessive model and logistic regression analysis that had been adjusted for age. This association was not found in native Japanese individuals. These results indicate that the rs235326 polymorphism in the ITGB2 gene is associated with obesity in Japanese living in the United States whose diet has become "westernized."