Upregulation of MicroRNA-107 induces proliferation in human gastric cancer cells by targeting the transcription factor FOXO1
Upregulation of MicroRNA-107 induces proliferation in human gastric cancer cells by targeting the transcription factor FOXO1
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DOI：
10.1016/j.febslet.2013.12.009
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发表时间：
2014-02-14
期刊：
影响因子：
3.5
通讯作者：
Zhang, Anping
中科院分区：
文献类型：
--
作者：
Li, Fan;Liu, Baohua;Zhang, Anping
MicroRNA-107 (miR-107) 已被证明可以调节多种癌症的增殖和凋亡。然而，其在胃癌中的生物学功能在很大程度上仍未被探索。在这里，我们发现与癌旁正常组织相比，胃癌中 miR-107 的表达水平升高。 miR-107的强制表达能够促进NCI-N87和AGS细胞的细胞增殖，而miR-107反义寡核苷酸（反义miR-107）则阻断细胞增殖。在分子水平上，我们的结果进一步揭示了FOXO1的表达受到miR-107的负调控。因此，本文报道的数据表明miR-107是胃癌的重要调节因子，这将有助于更好地了解胃癌中重要的错误调节的miRNA。 (C) 2014 年由 Elsevier B.V. 代表欧洲生化学会联合会出版。
MicroRNA-107 (miR-107) has been demonstrated to regulate proliferation and apoptosis in many types of cancers. Nevertheless, its biological function in gastric cancer remains largely unexplored. Here, we found that the expression level of miR-107 was increased in gastric cancer in comparison with the adjacent normal tissues. The enforced expression of miR-107 was able to promote cell proliferation in NCI-N87 and AGS cells, while miR-107 antisense oligonucleotides (antisense miR-107) blocked cell proliferation. At the molecular level, our results further revealed that expression of FOXO1 was negatively regulated by miR-107. Therefore, the data reported here demonstrate that miR-107 is an important regulator in gastric cancer, which will contribute to a better understanding of the important mis-regulated miRNAs in gastric cancer. (C) 2014 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.