Stille/Diels-Alder reaction sequences:: Diversity-oriented access to novel steroids
Stille/Diels-Alder reaction sequences:: Diversity-oriented access to novel steroids
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DOI：
10.1021/ol062878m
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发表时间：
2007-02-01
期刊：
影响因子：
5.2
通讯作者：
de Meijere, Armin
中科院分区：
文献类型：
--
作者：
Suennemann, Hans Wolf;Hofmeister, Anja;de Meijere, Armin
An efficient, diversity-oriented approach to novel steroid analogues possessing a C-5 beta configuration begins with the Stille cross-coupling of enantiomerically pure cycloalkenylstannane trans-2 and enol triflate 3. The resulting diene trans-4 engages in Diels-Alder cycloaddition reactions with a range of dienophiles to give, after removal of protecting groups, biologically interesting 6,7-disubstituted steroid analogues.
