The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: A meta-analysis
The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: A meta-analysis
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DOI：
10.1016/j.ahj.2007.06.037
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发表时间：
2007-11-01
影响因子：
4.8
通讯作者：
Arora, Rohit
中科院分区：
文献类型：
--
作者：
Bahekar, Amol Ashok;Singh, Sarabjeet;Arora, Rohit
背景先前的研究表明，关于牙周炎(PD)是否与冠心病(CHD)风险增加相关，结果相互矛盾。本研究的目的是评估这种关联是否存在。方法对文献进行系统回顾，发现符合Meta分析条件的5项前瞻性队列研究(随访6年)、5项病例对照研究和5项横断面研究。个别研究调整了混杂因素，如年龄、性别、糖尿病和吸烟。对这3个研究类别分别进行分析。采用Cochran q检验评价研究的异质性。结果5项前瞻性队列研究(86092例)的荟萃分析显示，帕金森病患者发生冠心病的风险是对照组的1.14倍(相对危险度为1.074~1.213，P<；.001)。病例对照研究(1 423例)显示发生冠心病的风险更大(OR2.22，95%CI1.59-3.117，P
Background Previous studies have shown conflicting results as to whether periodontitis (PD) is associated with increased risk of coronary heart disease (CHD). The aim of the current study was to evaluate whether such an association exists.Methods A systematic review of the literature revealed 5 prospective cohort studies (follow-up >6 years), 5 case-control studies, and 5 cross-sectional studies that were eligible for meta-analysis. Individual studies were adjusted for confounding factors such as age, sex, diabetes mellitus, and smoking. The 3 study categories were analyzed separately. Heterogeneity of the studies was assessed by Cochran Q test. The studies were homogeneous; therefore, the Mantel-Haenszel fixed-effect model was used to compute common relative risk and odds ratio (OR).Results Meta-analysis of the 5 prospective cohort studies (86092 patients) indicated that individuals with PD had a I. 14 times higher risk of developing CHD than the controls (relative risk 1.14, 95% CI 1.074-1.213, P < .001). The case-control studies (1423 patients) showed an even greater risk of developing CHD (OR 2.22, 95% Cl 1.59-3.117, P