Functional Group-Dependent Screening of Organophosphate Esters (OPEs) and Discovery of an Abundant OPE Bis-(2-ethylhexyl)-phenyl Phosphate in Indoor Dust
Functional Group-Dependent Screening of Organophosphate Esters (OPEs) and Discovery of an Abundant OPE Bis-(2-ethylhexyl)-phenyl Phosphate in Indoor Dust
复制标题
DOI：
10.1021/acs.est.9b07412
复制
发表时间：
2020-04-07
影响因子：
11.4
通讯作者：
Su，Guanyong
中科院分区：
文献类型：
--
作者：
Meng，Weikun;Li，Jianhua;Su，Guanyong
有机磷酸酯（OPEs）引起的环境污染和对公众健康的影响越来越受到科学界的关注。利用液相色谱-四极杆轨道阱高分辨质谱联用技术，基于分子裂解的特征，建立了一种新的、稳健的、非靶向的室内灰尘样品中新型OPEs的筛选策略，并在南京市室内灰尘样品的混合提取物中检测到12种先前报道的OPEs和6种先前未识别的OPEs，中国东部通过将独特的LC和MS特征与合成的纯标准品进行比较，鉴别了6种检测到的OPEs之一，即双-（2-乙基己基）-苯基磷酸酯（BEHPP）。BEHPP的准确浓度测定在= 50个单独的室内灰尘样品中，具有100%的检测频率，中值浓度范围为50 - 1530 ng/g干重，其通常大于或至少与传统的OPEs相当，即，磷酸三苯酯和2-乙基己基二苯基磷酸酯（EHDPP），在相同的灰尘样品中。BEHPP与EHDPP（r2 = 0.7884，p <0.0001）和BEHPP与磷酸三（2-乙基己基）酯（r2 = 0.4054，p <0.0001）的对数转换浓度之间存在统计学显著的正相关性，表明它们在环境中的商业应用和来源相似。
There is increasing scientific interest in environmental pollution and the effect on public health caused by organophosphate esters (OPEs). Using liquid chromatography coupled to a hybrid quadrupole Orbitrap high-resolution mass spectrometer, a novel, robust, and untargeted screening strategy for the identification of novel OPEs in indoor dust samples was presently developed based on the characteristic molecular fragmentation pathways, and 12 previously reported OPEs and six previously unrecognized OPEs were detected in the combined extracts of indoor dust samples, collected in Nanjing, eastern China. One of the six detected OPEs, bis-(2-ethylhexyl)-phenyl phosphate (BEHPP), was identified by comparison of unique LC and MS characteristics with a synthesized pure standard. Accurate concentrations of BEHPP were determined inn= 50 individual indoor dust samples with 100% detection frequency with a median concentration range of 50–1530 ng/g dry weight, which were generally greater or at least comparable to traditional OPEs, that is, triphenyl phosphate and 2-ethylhexyl diphenyl phosphate (EHDPP), in the same dust samples. Statistically significant, positive correlations were found for log-transformed concentrations of BEHPP versus EHDPP (r2= 0.7884,p< 0.0001), and BEHPP versus tris(2-ethylhexyl)phosphate (r2= 0.4054,p< 0.0001), suggesting their similar commercial applications and sources in the environment.