CEREBELLAR‐ATAXIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH HYPOTHYROIDISM UNDER TREATMENT
CEREBELLAR‐ATAXIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH HYPOTHYROIDISM UNDER TREATMENT
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正在治疗的患有甲状腺功能减退症的儿童和青少年小脑共济失调综合征
DOI：
10.1111/j.1651-2227.1976.tb16537.x
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
J. Wiebel
中科院分区：
文献类型：
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作者：
J. Wiebel
抽象的。动物实验和对人类小脑数量生长的观察表明，它的发育特别容易受到甲状腺功能减退症的影响。对 67 名长期治疗的 7-24 岁甲状腺功能减退症患者进行了共济失调症状检查。在 39 名患者中，有 24 名 (60%) 在出生前或出生后第三个月期间出现甲状腺功能减退症。 18 名甲状腺功能减退患者中只有 4 名 (20%) 后来出现小脑症状。这些症状可能是出生后第 3 个月之前或期间出现甲状腺功能减退症的证据。 17 名（80%）智障患者出现小脑症状，而 45 名就读正常学校的智障患者中只有 11 名（30%）出现小脑症状。即使回顾起来，这些数据也可能允许对甲状腺功能减退儿童的进一步智力发育进行更准确的预测。
ABSTRACT. Animal experiments and observations on quantitative growth of human cerebellum suggest a critical period when its development is particularly vulnerable to hypothyroidism. Sixty‐seven patients aged 7–24 years with hypothyroidism under long‐term treatment were examined for ataxic symptoms. These were found in 24 of 39 patients (60%) hypothyroid before or during the third month of life. Only 4 of 18 patients (20 %) hypothyroid later had cerebellar symptoms. Such symptoms could be evidence for the onset of hypothyroidism before or during the 3rd month of life. Seventeen (80%) of mentally retarded patients had cerebellar symptoms compared with 11 (30%) of 45 attending normal school. Even retrospecitvely, these data might permit a more accurate prognosis of further mental development in hypothyroid children.