Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events
Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events
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DOI：
10.1161/01.cir.99.16.2079
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发表时间：
1999-04-27
期刊：
影响因子：
37.8
通讯作者：
Maseri, A
中科院分区：
文献类型：
--
作者：
Biasucci, LM;Liuzzo, G;Maseri, A
背景：越来越多的证据表明炎症在急性冠状动脉综合征中的作用。本研究的目的是评估促炎细胞因子的作用，它们的时间过程，以及它们与不稳定心绞痛预后的关系。方法和结果：我们研究了43例年龄62+/-8岁的冠状动脉护理部门收治的brunwald IIIB型不稳定心绞痛患者。在每位患者入院时和入院后48小时测量血清白细胞介素-1受体拮抗剂（IL-1Ra）、白细胞介素-6 (IL-6)（分别代表生物活性IL-1 β和肿瘤坏死因子α水平的敏感标志物）和肌钙蛋白T水平。肌钙蛋白t阳性患者排除在外。根据住院情况将患者后诊分为两组：1组17例病程平稳，2组26例病程复杂。在第1组，平均IL-1Ra在48小时下降12%，IL-6在48小时下降13%；2组小鼠IL-1Ra和IL-6水平高于1组，48 h时分别升高37%和57% (P
Background-A growing body of evidence suggests a role for inflammation in acute coronary syndromes. The aim of this study was to assess the role of proinflammatory cytokines, their time course, and their association with prognosis in unstable angina.Methods and Results-We studied 43 patients aged 62+/-8 years admitted to our coronary care unit for Braunwald class IIIB unstable angina. In each patient, serum levels of interleukin-l receptor antagonist (IL-1Ra), interleukin-6 (IL-6) (which represent sensitive markers of biologically active IL-1 beta and tumor necrosis factor-alpha levels, respectively), and troponin T were measured at entry and 48 hours after admission. Troponin T-positive patients were excluded. Patients were divided a posteriori into 2 groups according to their in-hospital outcome: group 1 comprised 17 patients with an uneventful course, and group 2 comprised 26 patients with a complicated in-hospital course. In group 1, mean IL-1Ra decreased at 48 hours by 12%, and IL-6 diminished at 48 hours by 13%; In group 2, IL-1Ra and IL-6 entry levels were higher than in group 1 and increased respectively by 37% and 57% at 48 hours (P