Epidemiological evidence for an infective basis in childhood leukaemia
Epidemiological evidence for an infective basis in childhood leukaemia
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DOI：
10.1177/146642409611600608
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发表时间：
1996-12-01
期刊：
影响因子：
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通讯作者：
Kinlen, LJ
中科院分区：
文献类型：
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作者：
Kinlen, LJ
儿童白血病的感染基础并不是一个新的怀疑（Kellett，1937）。微生物学家未能确定任何特定的病原体，流行病学家未能证明疾病的明显时空聚集性（Smith，1382），这是令人沮丧的，但两者都与感染性起源不相容。在一些脊椎动物物种中，导致白血病的特定因子属于一类非常难以分离的物质。此外，许多传染病不会聚集在一起，因为它们是对相关感染的罕见反应。因此，引起传染性单核细胞增多症的病原体主要不是由患病者传播的，而是由大量临床上未受影响（或仅轻微影响）的受感染个体传播的。这类感染可被认为是“主要免疫性”：它们可被视为代表儿童白血病潜在感染所属的最可能的广泛类别。
An infective basis for childhood leukaemia is not a new suspicion (Kellett, 1937). The failure of microbiologists to identify any specific agent and of epidemiologists to demonstrate marked space-time clustering of the disease (Smith, 1382) have been discouraging, but neither is incompatible with an infectious origin. In several vertebrate species, the specific agents responsible for leukaemia belong to a class that is notoriously difficult to isolate. Also, many infectious illnesses do not cluster because they are uncommon responses to the relevant infection. Thus, the agent responsible for infectious mononucleosis is mainly spread not by those with the illness but by that very much larger number of infected individuals who are clinically unaffected (or only trivially so). Such infections can be considered as 'mainly immunising': they can be seen as representing the most probable broad category to which the infection underlying childhood leukaemia belongs.