Role of Interleukin 23 Signaling in Clostridium difficile Colitis
Role of Interleukin 23 Signaling in Clostridium difficile Colitis
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DOI：
10.1093/infdis/jit277
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发表时间：
2013-09-15
影响因子：
6.4
通讯作者：
Petri, William A., Jr.
中科院分区：
文献类型：
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作者：
Buonomo, Erica L.;Madan, Rajat;Petri, William A., Jr.
艰难梭菌目前是美国医院获得性感染的主要原因。在此，我们观察到C.艰难梭菌毒素的水平，与阴性对照相比（P= 0.008）。difficile感染，使用2种不同的鼠模型。与对照小鼠（16.7%-50% [12只小鼠]）相比，缺乏IL-23信号传导的小鼠的存活率显著增加（100% [12只小鼠]）。这些数据表明，一个新的潜在的药物靶点的人C。艰难的治疗，并表明在鼠感染期间IL-23和疾病严重程度之间的第一个联系。
Clostridium difficile is currently the leading cause of hospital-acquired infections in the United States. Here, we observed increased interleukin 23 (IL-23) protein levels in human colon biopsy specimens positive for C. difficile toxins, compared with levels in negative controls (P=.008) We also investigated the role of IL-23 during C. difficile infection, using 2 distinct murine models. Mice lacking IL-23 signaling had a significant increase in survival (100% [12 mice]), compared with control mice (16.7%-50% [12 mice]). These data suggest a new potential drug target for human C. difficile treatment and indicate the first link between IL-23 and disease severity during murine infection.