Renal excretion of ascorbic acid: effect of age and sex.
Renal excretion of ascorbic acid: effect of age and sex.
复制标题
抗坏血酸的肾脏排泄：年龄和性别的影响。
DOI：
10.1080/07315724.1993.10718349
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发表时间：
1993
影响因子：
3.5
通讯作者：
Garry,PJ
中科院分区：
文献类型：
--
作者：
Oreopoulos,DG;Lindeman,RD;VanderJagt,DJ;Tzamaloukas,AH;Bhagavan,HN;Garry,PJ
为了确定在男性中观察到的血浆抗坏血酸浓度低于女性，以及在一般老年人中，是否可能是由于抗坏血酸的肾清除率的差异，在老年人中测定了肾小管最大排斥（TmAA）和抗坏血酸的肾阈值。（10名男性，10名女性，年龄70-86岁）和更年轻（3名男性，5名女性，年龄26-59岁）的受试者。男性的平均TmAA为1.54 +/-0.29，女性为1.39 +/-0.33 mg/min/100 mL肾小球滤过率（p > 0.05）。男性的平均肾阈值为1.51 +/-0.25，女性为1.26 +/-0.16 mg/dL（p < 0.02）。也不受年龄的影响。如果TmAA和肾阈值的差异可以解释雄性动物中观察到的血浆抗坏血酸浓度较低，则两个值均应低于雌性动物。女性维持较高血浆抗坏血酸浓度的能力高于男性，年轻人高于老年人，不能用肾脏处理抗坏血酸的差异来解释。
To determine if the lower plasma ascorbic acid concentrations observed in males compared to females, and in the elderly in general, might be due to differences in renal clearances of ascorbic acid, tubular maximum reabsorptions (TmAA) and renal thresholds for ascorbic acid were determined on older (10 male, 10 female, aged 70-86 years) and younger (3 male, 5 female, aged 26-59 years) subjects. The mean TmAA for men was 1.54 +/− 0.29 and for women 1.39 +/− 0.33 mg/minute/100 mL glomerular filtration rate (p > 0.05). The mean renal threshold for men was 1.51 +/− 0.25 and for women 1.26 +/− 0.16 mg/dL (p < 0.02). Neither was affected by age. If differences in TmAA and renal threshold were to explain the lower plasma ascorbic acid concentrations observed in males, both values should have been lower than in females. The ability of women to maintain higher plasma ascorbic acid concentrations than men, and young higher than elderly, cannot be explained by differences in the renal handling of ascorbic acid.