CHARACTERIZATION AND DIFFERENTIATION OF POLYPOIDAL CHOROIDAL VASCULOPATHY USING SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
CHARACTERIZATION AND DIFFERENTIATION OF POLYPOIDAL CHOROIDAL VASCULOPATHY USING SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
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DOI：
10.1097/iae.0000000000001391
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发表时间：
2017-08-01
影响因子：
3.3
通讯作者：
Wong, Tien Yin
中科院分区：
文献类型：
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作者：
Cheung, Chui Ming Gemmy;Yanagi, Yasuo;Wong, Tien Yin
目的：确定扫源光学相干断层扫描血管造影 (SS-OCT-A) 与荧光素血管造影 (FA)、吲哚菁绿血管造影 (ICGA) 和频域 OCT (SD-OCT) 在表征息肉状脉络膜血管病变 (PCV) 和区分典型年龄相关性黄斑变性 (t-AMD) 眼睛方面的相关性和一致性。方法：本研究包括 32 名和分别有 54 只患有 t-AMD 和 PCV 的眼睛接受了 SS-OCT-A、SD-OCT、荧光素血管造影和吲哚青绿血管造影。比较这四种技术的图像。结果：在 SS-OCT-A 上，分别在 81.2% 和 77.8% 的 t-AMD 和 PCV 眼睛中检测到具有血管网络配置的血流信号。 40.4% 的息肉被检测为具有息肉状结构的流信号。与吲哚菁绿血管造影相比，SS-OCT-A对血管网的敏感性和特异性分别为83.0%和57.1%，对息肉的敏感性和特异性分别为40.5%和66.7%。 90% 的眼睛中 SS-OCT-A 和 SD-OCT 的纵向变化一致。 SD-OCT 中 88.2% 的视网膜干燥的眼睛在 SS-OCT-A 中具有持续性血管网。在两例 PCV 重新激活的病例中，SS-OCT-A 在检测复发方面比 SD-OCT 更敏感。结论：扫频光学相干断层扫描血管造影可有效检测 t-AMD 和 PCV 眼中与传统血管造影相关的血管网络。扫频光学相干断层扫描血管造影在检测息肉方面不如吲哚菁绿血管造影，并且不能替代吲哚菁绿血管造影来区分PCV和t-AMD；然而，SS-OCT-A 在检测早期复发方面可能比 SD-OCT 更敏感。
Purpose: To determine the correlation and agreement between swept-source optical coherence tomography angiography (SS-OCT-A) with fluorescein angiography (FA), indocyanine green angiography (ICGA) and spectral domain OCT (SD-OCT) in characterizing polypoidal choroidal vasculopathy (PCV) and in differentiating eyes with typical age-related macular degeneration (t-AMD).Methods: This study included 32 and 54 eyes with t-AMD and PCV, respectively, who underwent SS-OCT-A, SD-OCT, fluorescein angiography, and indocyanine green angiography. The images from these four techniques were compared.Results: On SS-OCT-A, flow signals with vascular network configuration were detected in 81.2% and 77.8% of eyes with t-AMD and PCV, respectively. 40.4% of polyps were detected as flow signals with polypoidal configuration. Compared with indocyanine green angiography, SS-OCT-A had sensitivity and specificity of 83.0% and 57.1%, respectively, for vascular network, and 40.5% and 66.7% for polyps. Longitudinal changes were in agreement between SS-OCT-A and SD-OCT in 90% of eyes. 88.2% of eyes with dry retina on SD-OCT had persistent vascular net on SS-OCT-A. In two cases with reactivation of PCV, SS-OCT-A was more sensitive at detecting recurrence than SD-OCT.Conclusion: Swept-source optical coherence tomography angiography is effective at detecting vascular network that correlate to conventional angiography in eyes with t-AMD and PCV. Swept-source optical coherence tomography angiography is inferior to indocyanine green angiography in detecting polyps and cannot replace indocyanine green angiography for differentiating PCV from t-AMD; however, SS-OCT-A may be more sensitive than SD-OCT in detecting early recurrence.