A neonatal atlas template for spatial normalization of whole-brain magnetic resonance images of newborns: Preliminary results
A neonatal atlas template for spatial normalization of whole-brain magnetic resonance images of newborns: Preliminary results
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DOI：
10.1016/j.neuroimage.2007.05.004
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发表时间：
2007-08-15
期刊：
影响因子：
5.7
通讯作者：
Wallois, Fabrice
中科院分区：
文献类型：
--
作者：
Kazemi, Kamran;Moghaddam, Hamid Abrishami;Wallois, Fabrice
常用的大脑模板是基于成人或儿童的大脑。在这项研究中，我们创建了一个新生儿大脑模板。这是必要的，因为成年人和儿童的大脑不仅在大小上，而且更重要的是与新生儿的大脑相比，在几何比例上存在明显差异。该模板是基于7名孕周在39至42周之间的个体在检查日期的高分辨率T1磁共振图像创建的。像往常一样，创建的模板在单个图像中呈现两个特征：平均强度和平均形状。使用SPM2（统计参数映射）及其变形工具箱完成将主题映射到相同空间的归一化过程。它包括两个步骤：仿射配准和非线性配准，分别用于全局和局部对齐。模板通过(i)研究解剖局部偏差和(W)规范化新生儿图像中脑组织局部变形的量来评估。将提取的结果与使用成人和儿童模板进行归一化的结果进行比较。结果表明，应用我们的新生儿大脑模板对新生儿图像进行对齐，可以显著提高规范化过程的性能，如减少解剖等效结构的偏差所示。(c) 2007爱思唯尔公司版权所有。
Commonly used brain templates are based on adults' or children's brains. In this study, we create a neonatal brain template. This becomes necessary because of the pronounced differences not only in size but even more importantly in geometrical proportions of the brains of adults and children as compared to the ones of newborns. The template is created based on high resolution T1 magnetic resonance images of 7 individuals with gestational ages between 39 and 42 weeks at the dates of examination. As usual, the created template presents two characteristics in a single image: an average intensity and an average shape. The normalization process to map subjects to the same space is done using SPM2 (Statistical Parametric Mapping) and its deformation toolbox. It consists of two steps: an affine and a nonlinear registration for global and local alignments, respectively. The template was evaluated by (i) study of anatomical local deviations and (W) amount of local deformations of brain tissues in normalized neonatal images. The extracted results were compared with the ones obtained by normalization using adult and pediatric templates. It was shown that the application of our neonatal brain template for alignment of neonatal images results in a pronounced increase in performance of the normalization procedure as indicated by reduction of deviation of anatomical equivalent structures. (c) 2007 Elsevier Inc. All rights reserved.