Tunneling nanotubes: Diversity in morphology and structure.
Tunneling nanotubes: Diversity in morphology and structure.
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DOI：
10.4161/cib.27934
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发表时间：
2014-01-01
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Austefjord MW;Gerdes HH;Wang X
Tunneling nanotubes（TNTs）是最近发现的连接细胞的薄膜管。在过去的十年中，研究表明TNT在形态和组成上是多样的，在细胞系统之间和细胞系统内都有变化。此外，TNT样细胞外突起的发现，以及TNT在体内的观察，进一步丰富了我们对TNT样结构的多样性的知识。考虑到TNTs形成的复杂分子机制，以及它们在细胞间通讯中的不同功能，重要的是要破译TNTs的异质性是如何建立的，并解决组成元素在执行各种功能中的作用。在这里，我们回顾了目前的知识形态和结构的多样性的TNTs，并解决之间的关系的形成，结构和功能的TNTs。
Tunneling nanotubes (TNTs) are recently discovered thin membranous tubes that interconnect cells. During the last decade, research has shown TNTs to be diverse in morphology and composition, varying between and within cell systems. In addition, the discovery of TNT-like extracellular protrusions, as well as observations of TNTs in vivo, has further enriched our knowledge on the diversity of TNT-like structures. Considering the complex molecular mechanisms underlying the formation of TNTs, as well as their different functions in intercellular communication, it is important to decipher how heterogeneity of TNTs is established, and to address what roles the compositional elements have in the execution of various functions. Here, we review the current knowledge on the morphological and structural diversity of TNTs, and address the relation between the formation, the structure, and the function of TNTs.