Psoriatic arthritis and human immunodeficiency virus infection in Zambia.
Psoriatic arthritis and human immunodeficiency virus infection in Zambia.
复制标题
赞比亚的银屑病关节炎和人类免疫缺陷病毒感染。
作者：
P. Njobvu;P. McGill
目的
描述赞比亚黑人银屑病关节炎（PsA）的临床特征以及PsA与人类免疫缺陷病毒（HIV）感染的关系。
方法
在40个月的时间内，对关节炎诊所就诊的表现出银屑病样病变的患者进行临床评估，并检测HIV抗体的存在。
结果
在702名患有炎症性关节炎的新参加者中，28名被指定为PsA，其中27名为HIV+。16名患者（60%）在介绍时是在WHO临床阶段I（无疾病或淋巴结病），相比之下，在阶段4（获得性免疫缺陷综合征，艾滋病）2。20例患者同时发生关节炎和银屑病。关节炎主要是多关节的、下肢的、进行性的。艾滋病发作时病情有所改善。银屑病通常是广泛的牙垢-斑块混合物，AIDS发作时无缓解。
结论
PsA几乎普遍与赞比亚黑人的艾滋病毒感染有关。临床特征与白人HIV相关PsA患者相似。
OBJECTIVE
To characterize the clinical features of psoriatic arthritis (PsA) in black Zambians and the association of PsA with human immunodeficiency virus (HIV) infection.
METHODS
Patients attending an arthritis clinic in a 40 month period who exhibited psoriasiform lesions were assessed clinically and tested for the presence of antibodies to HIV.
RESULTS
Of 702 new attendees with inflammatory arthritis 28 were designated as PsA and 27 of these were HIV+. Sixteen patients (60%) at presentation were in WHO clinical stage I (no disease or lymphadenopathy alone) compared to 2 in stage 4 (acquired immune deficiency syndrome, AIDS). Arthritis and psoriasis developed simultaneously in 20 patients. The arthritis is predominantly polyarticular, lower limb, and progressive. Amelioration was noted with onset of AIDS. Psoriasis was commonly an extensive guttate-plaque admixture and nonremittive with onset of AIDS.
CONCLUSION
PsA is almost universally associated with HIV infection in black Zambians. The clinical features are similar to those described in Caucasians with HIV associated PsA.