The colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. 3. Replication and differentiation in human hyperplastic and adenomatous polyps.
The colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. 3. Replication and differentiation in human hyperplastic and adenomatous polyps.
复制标题
结肠周围成纤维细胞鞘：成体组织中间充质细胞系统的复制、迁移和细胞分化。
DOI：
10.1016/s0016-5085(71)80056-2
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发表时间：
1971
期刊：
影响因子：
29.4
通讯作者：
N. Lane
中科院分区：
文献类型：
--
作者：
G. Kaye;R. Pascal;N. Lane
人增生性和腺瘤性结肠息肉的腺周成纤维细胞鞘的电子显微镜和放射自显影研究证实了Lane等人的建议（Lane N，Kaplan H，Pascal RR：Minute adenomatous and hyperplastic polyps of the colon：divergent patterns of epithelial growth with specific associated mesenchymal changes.在癌的发病机制中的对比作用。Gastroenterology 60：537-551，1971），这两种病变可能代表结肠粘膜正常分化的不同极端。增生粘膜的鞘完全分化并过度发育，与上覆上皮的分化和发育正好平行。相反，腺瘤上皮鞘的不成熟，表现为成纤维细胞在所有水平的持续分裂，成纤维细胞形态成熟的失败，以及成纤维细胞分泌其正常细胞外产物、胶原蛋白和粘多糖的失败，与上覆腺瘤上皮的不成熟程度平行。这些发现的临床意义进行了讨论。
Electron microscopic and autoradiographic studies of the pericryptal fibroblast sheath of human hyperplastic and adenomatous colonic polyps confirm the suggestion of Lane et al. (Lane N, Kaplan H, Pascal RR: Minute adenomatous and hyperplastic polyps of the colon: divergent patterns of epithelial growth with specific associated mesenchymal changes. Contrasting roles in the pathogenesis of carcinoma. Gastroenterology 60:537–551, 1971) that these two lesions may represent divergent extremes of the normal differentiation of the colonic mucosa. The sheath of the hyperplastic mucosa is fully differentiated and excessively developed, paralleling precisely the differentiation and development of the overlying epithelium. Conversely, the immaturity of the sheath of the adenomatous epithelium, demonstrated by continued fibroblast division at all levels, failure of morphological maturation of the fibroblasts, and failure of the fibroblasts to secrete their normal extracellular products, collagen and mucopolysaccharides, parallels the degree of immaturity of the overlying adenomatous epithelium. The clinical significance of these findings is discussed.