Malignant peritoneal mesothelioma
Malignant peritoneal mesothelioma
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DOI：
10.1002/jso.20266
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发表时间：
2005-07-01
影响因子：
2.5
通讯作者：
Gharaibeh, KA
中科院分区：
文献类型：
--
作者：
Bani-Hani, KE;Gharaibeh, KA
背景与目的：恶性腹膜间皮瘤（MPM）的发病率呈上升趋势。我们的目的是提出我们的经验，这个实体，以提高对这种疾病的认识，以避免误诊。方法：7例经病理证实的MPM的记录进行了回顾性分析。结果：有两名女性和5名男性，平均年龄为50.3岁（范围16-73）。两名患者记录了砷暴露，一名患者记录了家族性地中海热，一名患者记录了既往放射治疗。主要表现为腹痛、腹胀。所有患者均未在术前得到诊断。诊断的平均延迟时间为10个月。在所有肿瘤中均发现钙视网膜蛋白表达。3例患者接受肿瘤细胞减灭术联合全身化疗。2例存活的患者为年轻女性患者，经腹腔镜偶然发现诊断，并接受了细胞减灭术联合术中温热腹腔内化疗（HIIC）治疗。中位生存期为19.7个月。死亡5例，平均生存10.2个月。结论：提高对MPM的认识，对防止误诊有重要意义。免疫组化在确诊中有重要作用。MPM仍然是一个困难的治疗挑战。彻底的细胞减灭术是目前治疗的基石，而HIIC是一个有前途的策略，在合适的患者。
Background and Objectives: The incidence of malignant peritoneal mesothelioma (MPM) is rising. Our aim was to present our experience with this entity in order to increase the awareness about this disease to avoid misdiagnosis.Methods: Records of seven patients with histologically confirmed MPM were retrospectively reviewed. Demographic and clinicopathological findings were studied in detail.Results: There were two females and 5 males; mean age was 50.3 years (range 16-73). Asbestos exposure was recorded in two patients, familial Mediterranean fever in one and previous radiation in one. Main presentations were abdominal pain and distension. None of the patients was diagnosed preoperatively. The average delay in diagnosis was 10 months. Calretinin expression was identified in all tumors. Three patients were treated with cytoreductive surgery combined with systemic chemotherapy. Two patients who remain alive were young female patients who were diagnosed by laparoscopic incidental findings and were treated with cytoreductive surgery combined with hyperthermic intraoperative intraperitoneal chemotherapy (HIIC). Median survival was 19.7 months. The average survival time of the five patients who died of their diseases was 10.2 months.Conclusions: An awareness of MPM is important to prevent misdiagnosis. Immunohistochemistry has an important role in confirming the diagnosis. MPM remains a difficult therapeutic challenge. Thorough cytoreductive surgery is the cornerstone of current treatment while HIIC is a promising strategy in suitable patients.