PATHO-PHYSIOLOGY OF CIRCULATING IMMUNE-COMPLEXES
PATHO-PHYSIOLOGY OF CIRCULATING IMMUNE-COMPLEXES
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DOI：
10.1002/art.1780250713
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
MANNIK, M
中科院分区：
文献类型：
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作者：
MANNIK, M
实验动物研究表明，含有IgG抗体的循环大晶格免疫复合物可被K供体细胞有效清除。免疫复合物的清除还受到复合物中抗原和抗体的性质以及库普弗细胞的功能能力的影响。肾小球中免疫复合物的存在可能通过循环免疫复合物的沉积或抗原-抗体复合物的局部形成而发展。循环的大晶格复合物沉积在肾小球内皮下和系膜区，而免疫复合物沉积在上皮下是局部形成的。在实验动物中形成的免疫复合物的病理生理学概念将有助于指导人类免疫复合物疾病的研究，包括系统性红斑狼疮（SLE）。免疫复合物在SLE和其他免疫复合物疾病中引起许多临床表现。致病性免疫复合物要么从循环中沉积下来，要么局部形成。在局部形成的免疫丛中，抗原是靶器官的一部分或不相关的抗原选择性地沉积在器官中，循环中的抗体与这些抗原发生反应。在这种疾病机制中，通常只涉及一个器官。相反，当循环中存在致病性免疫复合物时，由于循环免疫复合物的沉积，通常涉及不止一个器官。本文将强调通过实验动物的研究而形成的概念，关于循环免疫管的命运和免疫复合物在肾小球中的沉积。提高对实验动物免疫复合物病理生理学的理解，将允许对人类疾病进行更深入的研究。
Studies in experimental animals have shown that circulating, large-latticed immune complexes containing IgG antibodiesareeffectiv ely removed by K upffer cells. The removal of immune complexes is also influenced by the nature of antigens and antibodies in the complexes and by the functional capacity of the Kupffer cells. The presence of immune complexes in glomeruli may develop by deposition of circulating immune complexes or by local formation of antigen-antibody compl exes. C irculati ng, large-latticed complexes deposi t in renal glomeruli in the subendothelial and mesangial areas, whereas subepithelial deposits of immune complexes are locally formed. Concepts on the pathophysiology of immune complexes developed in experimental animals will help to guide the study of human immune complex diseases, including systemic lupus erythema tosus (SLE).Immune complexes cause a number of clinical manifestations in SLE and in other immune complex disease. The pathogenic immune complexes are either deposited from thecirculationorlocal ly formed. I nlocal formation of immune canplexes, the antigens are part of the target organ or unrelated antigens are selectively deposited in the organ and antibodies fran the circulation react with these antigens. In this type of disease mechanism usually one organ is involved. In contrast, when pathogenic immune complexes are present in circulation, usually more than one organ is involved due to the deposition of circulating immune canplexes. This article will emphasize concepts, developed by study of experimental animals, on the fate of circulating imne canplexes and the deposition of immune complexes in renal glomeruli. Improved understanding of the pathophysiology of immune complexes in experimental animals will permit more incisive inquiry into human diseases.