Hsp90 and developmental networks.
Hsp90 and developmental networks.
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DOI：
10.1007/978-0-387-39975-1_16
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发表时间：
2007
影响因子：
--
通讯作者：
S. Rutherford;J. Knapp;P. Csermely
中科院分区：
文献类型：
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作者：
S. Rutherford;J. Knapp;P. Csermely
Hsp90 是真核细胞中最丰富的细胞质伴侣，是发育调控网络的枢纽，也是描述分子缓冲现象的第一个例子。作为许多不同信号蛋白的伴侣，Hsp90 保持细胞内和细胞间通讯的清晰度和强度，隐藏发育和随机变化，否则会导致包括果蝇和拟南芥在内的多种生物体发生突然的形态变化。本章提供了一个框架来理解 Hsp90 如何控制新形态的突然出现。我们首先讨论了隐藏的多基因变异这一长期存在的问题，然后介绍了信号转导阈值在调节 Hsp90 对表型变异表达的影响中的想法。这引发了对非线性在为细胞对发育信号的反应突然变化创建阈值方面的作用的讨论。最后我们推测 Hsp90 在控制决定形态停滞和进化变化的发育网络中的潜在关键作用。
The most abundant cytoplasmic chaperone of eukaryotic cells, Hsp90 is a hub in developmental regulatory networks and the first example described of the phenomenon of molecular buffering. As a chaperone for many different signaling proteins, Hsp90 maintains the clarity and strength of communication within and between cells, concealing developmental and stochastic variations that otherwise cause abrupt morphological changes in a large variety of organisms, includingDrosophilaandArabidopsis. The chapter provides a framework for understanding how Hsp90 controls the sudden appearance of novel morphologies. We start with a discussion of the longstanding problem of hidden polygenic variation and then introduce the idea of signal transduction thresholds in mediating the effect of Hsp90 on the expression of phenotypic variation. This leads to a discussion of the role of nonlinearity in creating thresholds for sudden changes in cellular responses to developmental signals. We end with speculation on the potentially pivotal role of Hsp90 in controlling the developmental networks that determine morphological stasis and change in evolution.