Interleukin-17 in pulmonary host defense
Interleukin-17 in pulmonary host defense
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DOI：
10.1080/01902140701756604
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发表时间：
2007-12-01
影响因子：
1.7
通讯作者：
Kolls, Jay K.
中科院分区：
文献类型：
--
作者：
Aujla, Shean J.;Dubin, Patricia J.;Kolls, Jay K.
白细胞介素（IL）-17 A和IL-17 F由一类称为Th 17细胞的新型效应α β T细胞产生，γ δ T细胞是α β IL-17产生性T细胞，由转录因子ROR γ t控制，并且独立于加塔-3、T-bet、Stat 4和Stat 6发育。由这些细胞产生的效应分子包括IL-17 A、IL-17 F和IL-22。IL-17 A和IL-17 F与IL-17受体（IL-17 R）结合，并且受体信号传导通过调节中性粒细胞迁移到感染组织部位的趋化因子梯度以及通过调节宿主粒细胞生成对于宿主防御细胞外细菌是关键的。此外，最近已经表明，IL-17和IL-22调节抗微生物蛋白的产生。上皮尽管Th 17细胞在机体免疫防御中是重要的，但在保留抗原刺激的情况下，如在哮喘或慢性感染的情况下，如在囊性纤维化中，或在自身免疫性的出售中，这些细胞可介导免疫病理学。
Interleukin (IL)-17A and IL-17F are produced by a novel class of effector alpha beta T cells called Th17 cells as well as gamma delta T cells are alpha beta IL-17-producing T cells are controlled by the tran.scriplio-n factor ROR gamma t and develop independent of GATA-3, T-bet, Stat 4, and Stat 6. Effector molecules produced by these cells include IL-17A, IL-17F, anal IL-22. IL-17A and IL-17F bind to IL-17 receptor (IL-17R) and receptor signaling is critical for host defense against, extracellular bacteria by regulating chemokine gradients for neutrophil emigration into infected tissue sites as well as via regulation of host granulopoiesis. Furthermore, it has recently been shown, that IL-17 and IL-22 regulate the production of antimicrobial proteins in. epithelium. Although Th17 cells are important in nntcosal host defense, in, the setting of retained antigenic stimulation, such as in the setting of asthma or chronic infection, such as in cystic fibrosis, or in the selling of autoimmnnity, these cells cart mediate imrnunopathology.