Conductivity-based detection techniques in nanofluidic devices.
Conductivity-based detection techniques in nanofluidic devices.
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DOI：
10.1039/c5an00075k
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发表时间：
2015-07-21
期刊：
影响因子：
--
通讯作者：
Jacobson SC
中科院分区：
文献类型：
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作者：
Harms ZD;Haywood DG;Kneller AR;Jacobson SC
本文综述了制备的纳米通道和纳米孔的电导检测。纳米级传感的改进是制造技术进步的直接结果，制造技术生产出具有可重复尺寸的通道和气孔的器件，并采用各种材料。当分析物在通道中积累或瞬时通过孔时，通过测量电导的变化来检测感兴趣的分析物。这些检测方法利用了纳米尺度上增强的现象，如离子电流整流、表面电导和与目标分析物相当的尺寸。最终的结果是为广泛的分析物，例如离子、小分子、蛋白质、核酸和颗粒开发传感技术。
This review covers conductivity detection in fabricated nanochannels and nanopores. Improvements in nanoscale sensing are a direct result of advances in fabrication techniques, which produce devices with channels and pores with reproducible dimensions and in a variety of materials. Analytes of interest are detected by measuring changes in conductance as the analyte accumulates in the channel or passes transiently through the pore. These detection methods take advantage of phenomena enhanced at the nanoscale, such as ion current rectification, surface conductance, and dimensions comparable to the analytes of interest. The end result is the development of sensing technologies for a broad range of analytes, e.g., ions, small molecules, proteins, nucleic acids, and particles.