Cone beam computed tomography based image guidance and quality assessment of prostate cancer for magnetic resonance imaging-only radiotherapy in the pelvis.
Cone beam computed tomography based image guidance and quality assessment of prostate cancer for magnetic resonance imaging-only radiotherapy in the pelvis.
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基于锥形束计算机断层扫描的影像引导和质量评估，用于仅行盆腔磁共振成像的前列腺癌放射治疗。
DOI：
10.1016/j.phro.2021.05.001
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发表时间：
2021-04
影响因子：
--
通讯作者：
Van Leemput K
中科院分区：
文献类型：
--
作者：
Edmund JM;Andreasen D;Van Leemput K
与CT相比，仅MRI的IGRT准确率为≤2 mm，但有显著差异。基于磁共振成像的基于CBCT的IGRT似乎是可行的，但建议谨慎。提出了SCT质量独立验证的中位数绝对误差(MeAE)。质量密度在0.1左右的MeAE可以要求进行SCT质量检测。基于磁共振成像(MRI)的放射治疗目前仅用于骨盆的临床应用。合成计算机断层扫描(SCT)是进行剂量规划所必需的。在这里，我们研究了基于锥束CT(CBCT)的MRI纯图像引导RT(IGRT)的准确性和SCT图像质量。包括10例前列腺癌患者的CT、MRI和CBCT扫描。使用多图谱方法将MRI转换为SCT。SCT、CT和MR图像与CBCT骨解剖图像自动匹配。建立成对的SCT-CT和SCT-CBCT数据。使用CT和SCT的标准校准曲线将CT数转换为相对电子密度(红色)和质量密度(DES)。对于CBCT RED/DES转换，使用了基于模体和配对CT-CBCT总体的校准曲线。对于后者，CBCT数在100个HU箱中取平均值，并指定CT的已知RED/DES。配对的SCT-CT和SCT-CBCT数据平均在10HU或0.01 RED/DES的箱中。计算SCT-CT和SCT-CBCT之间的中位绝对误差(MeAE)。对IGRT和MeAE研究进行了Wilcoxon秩和检验。SCT或MR IGRT与CT的平均差值为≤=2 mm，但差异有统计学意义。CBCT HU或基于模体的RED/DES MeAE没有评估SCT质量，类似于基于CT的MEAE，但基于CBCT人群的RED/DES MeAE评估了SCT质量。基于磁共振成像的基于CBCT的IGRT似乎是可行的，但建议谨慎。MEAE在0.1DES左右即可要求进行SCT质量检验。
MRI-only IGRT accuracy is ≤2 mm as compared to CT but significant differences were observed. MRI-only CBCT-based IGRT seems feasible but caution is advised. The median absolute error (MeAE) for independent verification on the sCT quality is proposed. A MeAE around 0.1 in mass density could call for sCT quality inspection. Radiotherapy (RT) based on magentic resonance imaging (MRI) only is currently used clinically in the pelvis. A synthetic computed tomography (sCT) is needed for dose planning. Here, we investigate the accuracy of cone beam CT (CBCT) based MRI-only image guided RT (IGRT) and sCT image quality. CT, MRI and CBCT scans of ten prostate cancer patients were included. The MRI was converted to a sCT using a multi-atlas approach. The sCT, CT and MR images were auto-matched with the CBCT on the bony anatomy. Paired sCT-CT and sCT-CBCT data were created. CT numbers were converted to relative electron (RED) and mass densities (DES) using a standard calibration curve for the CT and sCT. For the CBCT RED/DES conversion, a phantom and paired CT-CBCT population based calibration curve was used. For the latter, the CBCT numbers were averaged in 100 HU bins and the known RED/DES of the CT were assigned. The paired sCT-CT and sCT-CBCT data were averaged in bins of 10 HU or 0.01 RED/DES. The median absolute error (MeAE) between the sCT-CT and sCT-CBCT bins was calculated. Wilcoxon rank-sum tests were carried out for the IGRT and MeAE study. The mean sCT or MR IGRT difference from CT was ≤ 2 mm but significant differences were observed. A CBCT HU or phantom-based RED/DES MeAE did not estimate the sCT quality similar to a CT based MeAE but the CBCT population-based RED/DES MeAE did. MRI-only CBCT-based IGRT seems feasible but caution is advised. A MeAE around 0.1 DES could call for sCT quality inspection.
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影响因子：
3.1
作者：
Korhonen, Juha;Kapanen, Mika;Tenhunen, Mikko
通讯作者：
Tenhunen, Mikko
影响因子：
3.1
作者：
Thing, Rune S.;Bernchou, Uffe;Brink, Carsten
通讯作者：
Brink, Carsten
影响因子：
5.7
作者：
Maspero, Matteo;Bentvelzen, Laura G.;Philippens, Marielle E. P.
通讯作者：
Philippens, Marielle E. P.
影响因子：
3.8
作者：
Andreasen, Daniel;Van Leemput, Koen;Edmund, Jens M.
通讯作者：
Edmund, Jens M.
影响因子：
3.8
作者：
Johansson, Adam;Karlsson, Mikael;Nyholm, Tufve
通讯作者：
Nyholm, Tufve