The amygdala is necessary for the expression of conditioned but not unconditioned analgesia.
The amygdala is necessary for the expression of conditioned but not unconditioned analgesia.
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DOI：
10.1037//0735-7044.107.2.402
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发表时间：
1993-04
影响因子：
1.9
通讯作者：
L. Watkins;E. Wiertelak;S. Maier
中科院分区：
文献类型：
--
作者：
L. Watkins;E. Wiertelak;S. Maier
杏仁核基底外侧区和中央核的损伤阻碍了条件性镇痛(Helmstetter，1992)。总体而言，杏仁核的这些区域更关键地参与了对厌恶事件的条件性反应的表达，而不是参与非条件性反应的中介。在SD大鼠中，研究了杏仁核损伤对条件性和非条件性镇痛的影响。皮损完全阻止条件性镇痛的表达，但对非条件性镇痛无影响。
Lesions of the basolateral region and central nucleus of the amygdala prevent conditioned analgesia (Helmstetter, 1992). In general, these regions of the amygdala are more critically involved in the expression of conditioned reactions to aversive events than in the mediation of unconditioned reactions. The impact of amygdala lesions on both conditioned and unconditioned analgesia was explored in Sprague-Dawley rats. The lesions completely prevented the expression of conditioned analgesia, but had no effect on unconditioned analgesia.