Early metabolic derangements in daughters of women with polycystic ovary syndrome
Early metabolic derangements in daughters of women with polycystic ovary syndrome
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DOI：
10.1210/jc.2007-1036
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发表时间：
2007-12-01
影响因子：
5.8
通讯作者：
Cassorla, Fernando
中科院分区：
文献类型：
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作者：
Sir-Petermann, Teresa;Maliqueo, Manuel;Cassorla, Fernando
背景：多囊卵巢综合征(PCOS)是一种家族性内分泌-代谢功能障碍，在患有高雄激素血症的青春期女孩中日益被认识。然而，很难确定PCOS中描述的代谢异常是否在高雄激素血症发生之前就存在。在儿童中，脂联素水平与胰岛素抵抗的代谢参数有很强的相关性。目的：本研究的目的是评估PCOS妇女青春期前和青春期女儿的脂联素水平和代谢参数，以确定有更高的代谢风险的女孩。设计：研究对象为PCOS妇女(PCOSd)的53个青春期前和22个青春期(Tanner II-V期)女儿，以及对照组妇女(CD)的32个青春期前和17个青春期女儿。两组患者均进行口服葡萄糖耐量试验，测量血糖和胰岛素水平。空腹测定脂联素、瘦素、C反应蛋白、SHBG、性激素和血脂。结果：两组的年龄、体重指数SD评分和Tanner分期分布相似。在青春期前女孩中，PCOSd组的2-h胰岛素水平高于Cd组(P=0.023)，脂联素水平低于Cd组(P=0.004)。在青春期女孩中，PCOS组的甘油三酯(P=0.03)、2 h胰岛素(P=0.01)和血清睾酮浓度(P=0.012)高于CD组(P=0.012)，SHBG低于CD组(P=0.009)，但两组脂联素水平相似。结论：PCOS患者的女儿在高雄激素血症发生之前就已表现出部分代谢特征。脂联素似乎是这些女孩代谢紊乱的早期标志之一。
Context: Polycystic ovary syndrome ( PCOS) is a familial endocrine-metabolic dysfunction, increasingly recognized in adolescent girls with hyperandrogenism. However, it is difficult to establish whether the metabolic abnormalities described in PCOS are present before the onset of hyperandrogenism. In children, a strong association of adiponectin levels with metabolic parameters of insulin resistance has been described.Objective: The objective of the study was to evaluate adiponectin serum concentrations and metabolic parameters in prepubertal and pubertal daughters of women with PCOS to identify girls with increased metabolic risk.Design: Fifty-three prepubertal and 22 pubertal ( Tanner stages II-V) daughters of PCOS women (PCOSd) and 32 prepubertal and 17 pubertal daughters of control women ( Cd) were studied. In both groups, an oral glucose tolerance test was performed with measurement of glucose and insulin. Adiponectin, leptin, C-reactive protein, SHBG, sex steroids, and lipids were determined in the fasting sample.Results: Both groups had similar chronological ages, body mass index SD score, and Tanner stage distribution. In the prepubertal girls, 2-h insulin was higher ( P = 0.023) and adiponectin levels were lower ( P = 0.004) in the PCOSd group, compared with the Cd group. In the pubertal girls, triglycerides ( P = 0.03), 2-h insulin ( P = 0.01), and serum testosterone concentrations were higher ( P = 0.012) and SHBG lower ( P = 0.009) in PCOSd, compared with Cd, but adiponectin levels were similar in both groups.Conclusions: Some of the metabolic features of PCOS are present in daughters of PCOS women before the onset of hyperandrogenism. Adiponectin appears to be one of the early markers of metabolic derangement in these girls.