Competitive exclusion of diarrheagenic Escherichia coli (ETEC) from human enterocyte-like Caco-2 cells by heat-killed Lactobacillus.
Competitive exclusion of diarrheagenic Escherichia coli (ETEC) from human enterocyte-like Caco-2 cells by heat-killed Lactobacillus.
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DOI：
10.1111/j.1574-6968.1992.tb05211.x
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发表时间：
1992-03
影响因子：
2.1
通讯作者：
Gilles Chauvière;Marie-Hélène Coconnier;S. Kernéis;Arlette Darfeuille-Michaud;Bernard Joly;A. Servin
中科院分区：
文献类型：
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作者：
Gilles Chauvière;Marie-Hélène Coconnier;S. Kernéis;Arlette Darfeuille-Michaud;Bernard Joly;A. Servin
携带CFA/I或CFA/II粘附因子的致泻性大肠杆菌（ETEC）特异性地粘附在培养的极化的人肠上皮Caco-2细胞的刷状缘上。粘附在Caco-2细胞上的热灭活的嗜酸乳杆菌菌株LB以浓度依赖性方式抑制产肠杆菌性大肠杆菌粘附。自从L.嗜酸乳杆菌不表达ETEC-CFA粘附因子，因此推测热灭活的嗜酸乳杆菌可能是嗜酸乳杆菌。嗜酸乳杆菌LB细胞抑制大肠杆菌E.通过人肠细胞ETEC受体的空间位阻作用使大肠杆菌附着。
Diarrheagenic Escherichia coli (ETEC) bearing CFA/I or CFA/II adhesive factors specifically adhere onto the brush border of the polarized epithelial human intestinal Caco-2 cells in culture. Heat-killed Lactobacillus acidophilus strain LB, that adheres onto Caco-2 cells, inhibits diarrheagenic Escherichia coli adhesion in a concentration-dependent manner. Since the L. acidophilus does not express ETEC-CFA adhesive factors, it can be postulated that the heat-killed L. acidophilus LB cells inhibit diarrheagenic E. coli attachment by steric hindrance of the human enterocytic ETEC receptors.