Influence of population density on antibiotic resistance
Influence of population density on antibiotic resistance
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DOI：
10.1093/jac/dkg072
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发表时间：
2003-02-01
影响因子：
5.2
通讯作者：
Stobberingh, EE
中科院分区：
文献类型：
--
作者：
Bruinsma, N;Hutchinson, JM;Stobberingh, EE
作为衡量社区拥挤程度的一项指标，抗生素消费量和人口密度与三个不同国家的三个城市的抗生素耐药性患病率有关：纽芬兰（加拿大）的圣约翰、希腊的雅典和荷兰的格罗宁根。抗生素用量以DDD（定义日剂量）表示，分别为DID （DDD/1000居民/天）和DSD （DDD/km(2)）。测定了健康志愿者粪便样本中耐抗生素大肠杆菌和肠球菌的流行情况。在纽芬兰（28 DID）和希腊（29 DID），抗生素的总消费量比荷兰（9 DID）高出三倍多。纽芬兰的样本对大多数抗生素的耐药率最低，头孢唑林、土霉素和甲氧苄啶的耐药率显著（P < 0.05）。观察到DID数量与耐药患病率之间的相关性较差[Pearson相关系数（Pcc）在-0.93至0.87之间]。然而，当考虑到人口密度并以DSD表示抗生素消费量时，观察到很强的相关性（Pcc范围在0.86至1.00之间）。该研究表明，人口密度是抗生素耐药性发展的一个重要因素，值得作为耐药性流行病学的一个因素予以特别关注。
Antibiotic consumption and population density as a measure of crowding in the community were related to the prevalence of antibiotic resistance of three cities in three different countries: St Johns in Newfoundland (Canada), Athens in Greece and Groningen in The Netherlands. Antibiotic consumption was expressed in DDD (defined daily dose), as DID (DDD/1000 inhabitants/day) and as DSD (DDD/km(2)). The prevalence of antibiotic-resistant Escherichia coli and enterococci was determined in faecal samples of healthy volunteers. In both Newfoundland (28 DID) and Greece (29 DID) the overall consumption of antibiotics was more than three times higher compared with that of The Netherlands (9 DID). The lowest prevalence of resistant E. coli against the majority of antibiotics tested was found for the samples from Newfoundland and was significant (P < 0.05) for cefazolin, oxytetracycline and trimethoprim. A poor correlation between the number of DID and the prevalence of resistance was observed [the Pearson correlation coefficient (Pcc) ranged between -0.93 and 0.87]. However, when population density was taken into consideration and antibiotic consumption was expressed in DSD, a strong correlation was observed (and Pcc ranged between 0.86 and 1.00). This study suggests that population density is an important factor in the development of antibiotic resistance and warrants special attention as a factor in resistance epidemiology.