Synthesis of phenanthridines by I-2-mediated sp(3) C-H amination
Synthesis of phenanthridines by I-2-mediated sp(3) C-H amination
复制标题
I-2 介导的 sp(3) C-H 胺化合成菲啶
DOI：
10.1039/d0ob00433b
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发表时间：
2020
影响因子：
3.2
通讯作者：
Chang Junbiao
中科院分区：
文献类型：
--
作者：
Fang Benyao;Hou Jiao;Tian Jinyue;Yu Wenquan;Chang Junbiao
本文报道了一种苯胺前体通过分子内sp3 C-H胺化反应合成苯胺的方法。目前的合成工艺简单，适用于各种无保护苯胺底物，并提供了方便和有效的获取菲苯胺衍生物。这个C-H胺化方案不使用过渡金属，操作简单，可以在克尺度上实现。
An I2-mediated synthesis of phenanthridines via intramolecular sp3 C–H amination of readily accessible aniline precursors is reported. The present synthetic process is straightforward and applicable to a broad variety of unprotected aniline substrates, and provides facile and efficient access to phenanthridine derivatives. This C–H amination protocol does not use transition metals, is operationally simple, and can be achieved on a gram scale.