Pituitary lymphoma developing within pituitary adenoma
Pituitary lymphoma developing within pituitary adenoma
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DOI：
10.1007/s12185-012-1075-0
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发表时间：
2012-06-01
影响因子：
2.1
通讯作者：
Kurokawa, Mineo
中科院分区：
文献类型：
--
作者：
Morita, Ken;Nakamura, Fumihiko;Kurokawa, Mineo
淋巴瘤发生在脑下垂体是一个非常罕见的事件。在这里，我们描述一个垂体淋巴瘤合并复发性垂体腺瘤的病例。一名56岁男性，有垂体腺瘤病史，被诊断为左眼附属器弥漫性大B细胞淋巴瘤（DLBCL），通过标准化疗和局部放疗成功治疗。八个月后，他主诉复视和双颞侧偏盲。脑部磁共振成像检测到鞍上肿瘤。经蝶窦穿刺活检，组织病理学检查显示DLBCL合并垂体腺瘤。回顾文献，我们发现垂体淋巴瘤在腺瘤内发展是一种复发现象。该复合肿瘤的特征可能是鞍上受累和视觉障碍。此外，在本病例中，自体外周干细胞移植后鞍上肿瘤仍然可见，可能是由于残留的垂体腺瘤。因此，我们建议对难治性垂体淋巴瘤应积极活检，以寻找潜在的腺瘤。
Lymphoma occurring in the pituitary gland is an exceedingly infrequent event. Here, we describe a case of pituitary lymphoma complicating recurrent pituitary adenoma. A 56-year-old male with a history of pituitary adenoma was diagnosed with diffuse large B-cell lymphoma (DLBCL) of the left ocular adnexa, which was successfully treated by standard chemotherapy and local radiotherapy. Eight months later, he complained of diplopia and bitemporal hemianopia. Brain magnetic resonance imaging detected a suprasellar tumor. Transsphenoidal biopsy of the mass was performed, and histopathological examination revealed DLBCL admixed with pituitary adenoma. On a review of the literature, we found that pituitary lymphoma developing within adenoma is a recurrent phenomenon. The composite tumor is likely to be characterized by suprasellar involvement and presentation of visual disturbances. Moreover, in the present case, the suprasellar tumor remained visible after autologous peripheral stem cell transplant, likely due to the residual pituitary adenoma. We therefore recommend that refractory pituitary lymphoma should be vigorously biopsied in search of possibly underlying adenoma.