CONTROL OF ACH SENSITIVITY BY MUSCLE ACTIVITY IN RAT
CONTROL OF ACH SENSITIVITY BY MUSCLE ACTIVITY IN RAT
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DOI：
10.1113/jphysiol.1972.sp009764
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发表时间：
1972-01-01
影响因子：
5.5
通讯作者：
ROSENTHAL, J
中科院分区：
文献类型：
--
作者：
LOMO, T;ROSENTHAL, J
1. 在麻醉或白喉毒素完全阻断坐骨神经冲动长达14天后，对大鼠比目鱼肌和指长伸肌（EDL）进行检查。2. 肌肉萎缩的程度与同样时间的去神经支配后的肌肉萎缩程度相当。3. 当通过神经阻滞以外的刺激测试时，神经阻滞似乎对神经肌肉传递几乎没有影响。正常自发微型终板电位存在。4. 神经冲动阻断导致整个肌膜对离子传导应用的乙酰胆碱变得敏感。5. 慢性神经刺激远端阻滞区可以防止比目鱼肌敏感性的增加。6. 肌腱切断术持续5 ~ 12天，造成肌肉萎缩，但对比目鱼肌对乙酰胆碱的敏感性无影响。7. 慢性直接刺激无神经支配的比目鱼肌或EDL肌，可以防止通常的去神经支配超敏反应，或使其在出现后下降到正常水平。然而，端板区域的灵敏度保持正常。图片
1. Rat soleus and extensor digitorum longus (EDL) muscles were examined following complete blockade of sciatic nerve impulses with anaesthetics or diphtheria toxin for periods up to 14 days. 2. Muscles showed atrophy equivalent to that seen after similar periods of denervation. 3. Nerve blockade appeared to have little or no effect on neuromuscular transmission when tested by stimulation beyond the block. Normal spontaneous miniature end-plate potentials were present. 4. Nerve impulse blockade caused the entire muscle membrane to become sensitive to iontophoretically applied acetylcholine. 5. The increase in sensitivity in soleus could be prevented by chronic nerve stimulation distal to the region of block. 6. Tenotomy, of 5-12 days duration, which produced atrophy, had no effect on the sensitivity of soleus to acetylcholine. 7. Chronic direct stimulation of denervated soleus or EDL muscles could prevent the usual denervation supersensitivity, or cause it to decline towards normal once it had appeared. However, the sensitivity of the end-plate region remained normal. Images