Improved cyclodextrin chiral phases: a comparison and review
Improved cyclodextrin chiral phases: a comparison and review
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DOI：
10.1080/01483918608076644
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发表时间：
1986-02
影响因子：
1.3
通讯作者：
T. Ward;D. Armstrong
中科院分区：
文献类型：
--
作者：
T. Ward;D. Armstrong
摘要环糊精手性相已被广泛应用于拆分对映体、非对映异构体、结构异构体和常规化合物。最近在这一领域发生了两项创新。首先，提高了β-环糊精柱的效率和选择性。第二，已经开发出了产生类似于柱的分离的相容的TLC板。这些结果将在对已发表的工作进行简要回顾后进行讨论。此外，还讨论了环糊精键合介质的拆分机理、溶剂效应、温度效应和结构效应对手性拆分的影响。
Abstract Cyclodextrin chiral phases have been shown to be widely applicable for the separation of enantiomers, diastereomers, structural isomers and routine compounds. Two innovations have recently occured in this field. First, the efficiency and selectivity of the β-cyclodextrin column has been improved. Second, compatable TLC plates which produce separations analogous to the columns have been developed. These results are discussed subsequent to a brief review of published work. In addition, the mechanism of separation on cyclodextrin bonded media, solvent effects, temperature effects and structural effects on chiral separations are considered.