Pulmonary cryptococcosis misdiagnosed as smear-negative pulmonary tuberculosis with fatal consequences
Pulmonary cryptococcosis misdiagnosed as smear-negative pulmonary tuberculosis with fatal consequences
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DOI：
10.1016/j.ijid.2010.02.2255
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发表时间：
2010-09-01
影响因子：
8.4
通讯作者：
Meintjes, Graeme
中科院分区：
文献类型：
--
作者：
Jarvis, Joseph N.;Wainwright, Helen;Meintjes, Graeme
HIV相关的肺隐球菌病诊断不足，并可能进展为致命性脑膜脑炎。我们报告一例HIV相关的新型隐球菌肺感染，最初被误诊为涂片阴性的肺结核病，后来发展为致命性的隐球菌性脑膜炎。尸检系列表明，肺隐球菌病在非洲艾滋病患者中很常见，由于诊断能力有限，经常被误诊为涂片阴性结核病。血清隐球菌抗原检测有助于此类病例的诊断。(C)2010年国际传染病学会。爱思唯尔有限公司出版。保留所有权利。
HIV-associated pulmonary cryptococcosis is under diagnosed, and may progress to fatal meningoencephalitis. We present a case of HIV-associated pulmonary Cryptococcus neoformans infection, initially mis-diagnosed as smear-negative pulmonary TB, which progressed to fatal cryptococcal meningitis. Autopsy series suggest that pulmonary cryptococcosis is common in African AIDS patients, and, due to limited diagnostic capacity, often mis-diagnosed as smear negative TB. Serum cryptococcal antigen testing may facilitate diagnosis in such cases. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.