NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers
NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers
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DOI：
10.1016/0893-133x(95)00137-3
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发表时间：
1996-05-01
影响因子：
7.6
通讯作者：
Breier, A
中科院分区：
文献类型：
--
作者：
Malhotra, AK;Pinals, DA;Breier, A
一个快速增长的临床前数据的主体已经牵连的NMDA受体在记忆和其他认知过程中的N-甲基-d-天冬氨酸（NMDA）。在人类认知中，关于这种受体系统的信息相对较少。我们研究了亚麻醉剂量的氯胺酮（一种非竞争性NMDA受体拮抗剂）对15名健康志愿者的两种形式的记忆、自由回忆和识别以及双盲、安慰剂对照、1小时输注的注意力和行为的影响。氯胺酮在自由回忆、再认记忆和注意力方面产生下降。此外，氯胺酮在我们的健康志愿者中诱导了短暂的精神病，表现为思维障碍和戒断迟缓。氯胺酮诱导的记忆障碍不占受试者注意力的变化，并没有显着相关的精神病评级。这些数据表明，NMDA受体在两种类型的外显记忆中起着直接的作用。这些数据的精神分裂症的病理生理学的影响进行了讨论。
A rapidly growing body of preclinical data has implicated the glutamatergic N-methyl-d-aspartate (NMDA) receptor in memory and other cognitive processes. There is comparatively less information about this receptor system in human cognition. We examined the effects of subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, on two forms of memory, free recall and recognition, as well as attention and behavior in a double-blind, placebo-controlled, 1-hour infusion in 15 healthy volunteers. Ketamine produced decrements in free recall, recognition memory, and attention. In addition, ketamine induced a brief psychosis in our healthy volunteers marked by thought disorder and withdrawal-retardation. Ketamine-induced memory impairments were not accounted for by changes in subject attention and were not significantly related to psychosis ratings. These data suggest that the NMDA receptor plays a direct role in two types of explicit memory. The implications of these data for the pathophysiology of schizophrenia are discussed.