A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning
A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning
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DOI：
10.1016/0092-8674(95)90146-9
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发表时间：
1995-12-29
期刊：
影响因子：
64.5
通讯作者：
Bourtchouladze, R
中科院分区：
文献类型：
--
作者：
Huang, YY;Kandel, ER;Bourtchouladze, R
使用遗传学方法，我们评估了蛋白激酶A（PKA）突变对杂乱纤维通路中长时程增强（LTP）的影响及其与空间和背景学习的关系。通过PKA的C β（1）或RI β亚型的基因靶向消融产生了凌乱纤维LTP的选择性缺陷，为这些亚型在凌乱纤维通路中的作用提供了遗传学证据。尽管消除了凌乱的纤维LTP，但对新奇事物的行为反应，空间学习和对环境的条件反射并不受影响。因此，与目前关于海马功能的理论相反，凌乱的纤维LTP似乎并不需要空间或上下文学习。在没有杂乱纤维LTP的情况下，足够的空间和上下文信息可能通过其他途径从内嗅皮层到达CA1区。
Using a genetic approach, we assessed the effects of mutations in protein kinase A (PKA) on long-term potentiation (LTP) in the messy fiber pathway and its relationship to spatial and contextual learning. Ablation by gene targeting of the C beta(1) or the RI beta isoform of PKA produces a selective defect in messy fiber LTP, providing genetic evidence for the role of these isoforms in the messy fiber pathway. Despite the elimination of messy fiber LTP, the behavioral responses to novelty, spatial learning, and conditioning to context are unaffected. Thus, contrary to current theories about hippocampal function, messy fiber LTP does not appear to be required for spatial or contextual learning. In the absence of messy fiber LTP, adequate spatial and contextual information might reach the CA1 region via other pathways from the entorhinal cortex.