First Total Synthesis of (-)-Auranomide C and Its Derivatives

First Total Synthesis of (-)-Auranomide C and Its Derivatives
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DOI:
10.1055/s-0033-1338558
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发表时间:
2014-01-01
影响因子:
2.6
通讯作者:
Pusuluri, Srinivas
Pusuluri, Srinivas
中科院分区:
化学4区
文献类型:
--
作者:
Sorra, Kumaraswamy;Mukkanti, K.;Pusuluri, Srinivas

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The first total synthesis of (-)-auranomide C has been achieved. The short synthetic strategy involves a reductive dehydro-cyclization and the nucleophilic ring opening of a fused gamma-lactam. The route allows for ease in synthesizing diverse derivatives in the side chain of the natural product.