Prevalence of Osteoporosis and Low Bone Mass in Older Chinese Population Based on Bone Mineral Density at Multiple Skeletal Sites.
Prevalence of Osteoporosis and Low Bone Mass in Older Chinese Population Based on Bone Mineral Density at Multiple Skeletal Sites.
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DOI：
10.1038/srep25206
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发表时间：
2016-05-04
影响因子：
4.6
通讯作者：
Chan WP
中科院分区：
文献类型：
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作者：
Lu YC;Lin YC;Lin YK;Liu YJ;Chang KH;Chieng PU;Chan WP
骨质疏松症的诊断是基于骨密度(BMD)的测量，该测量依赖于部位，并且测量部位之间通常不一致。我们的目的是根据双能X射线骨密度仪(DXA)在不同部位(仅腰椎(LS)、股骨颈(FN)或两者兼而有之)测量的BMD T分数来确定诊断为骨质疏松症的患病率。共有1712名女性和2028名男性接受了LS和FN骨密度测量。在LS和FN测量的T评分基础上，发现骨质疏松分类之间有超过50%的不一致。使用在LS和左右FN(而不是一个部位)测量的最低T分数显著增加了绝经后妇女的骨质疏松症患病率，从4.03%增加到10.75%，在≧50岁的男性中从1.82%增加到4.29%(p <； 0.001)。总体和年龄调整后的骨质疏松患病率在女性和男性中的趋势相似。如果使用美国参考而不是亚洲参考来计算T分数，骨质疏松症的诊断率更高(26.64%比10.75%)。综上所述，基于多部位骨密度测量的最低T分数的诊断可以增加骨质疏松症的患病率，表明多部位测量策略具有更高的敏感性。
Diagnosis of osteoporosis is based on bone mineral density (BMD) measurement, which is site dependent and commonly discordant between measurement sites. We aimed to determine the prevalence of osteoporosis diagnosed based on BMD T-scores measured by dual-energy x-ray absorptiometry (DXA) at different sites: the lumbar spine (LS) alone, femoral neck (FN) alone, or both. A total of 1712 women and 2028 men with LS and FN BMD measurements were enrolled. Over 50% discordance was found between osteoporosis classifications based on T-scores measured at the LS and FN. Use of the lowest T-scores measured at both the LS and right and left FN (rather than one site) significantly increased the prevalence of osteoporosis from 4.03 to 10.75% in postmenopausal women and 1.82 to 4.29% in men aged ≧50 years (p < 0.001). The trends of overall and age-adjusted prevalence of osteoporosis were similar in women and men. Osteoporosis was diagnosed at a higher rate if the USA reference rather than the Asia reference was used to calculate the T-score (26.64% vs. 10.75%). In conclusion, diagnosis based on the lowest T-score from multiple site BMD measurement can increase the prevalence of osteoporosis, demonstrating the higher sensitivity of the multiple site measurement strategy.