Expression and Clinical Significance of Hepatoma-Derived Growth Factor as a Prognostic Factor in Human Hilar Cholangiocarcinoma
Expression and Clinical Significance of Hepatoma-Derived Growth Factor as a Prognostic Factor in Human Hilar Cholangiocarcinoma
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DOI：
10.1245/s10434-010-1303-x
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发表时间：
2011-03-01
影响因子：
3.7
通讯作者：
Xu, Ke-sen
中科院分区：
文献类型：
--
作者：
Liu, Yan-feng;Zhao, Rui;Xu, Ke-sen
肝癌衍生生长因子（HDGF）和血管内皮生长因子（VEGF）的过度表达在肿瘤的发生发展中起重要作用。本研究采用免疫组化SP法检测58例肝门部胆管癌患者手术切除标本中HDGF和VEGF的表达，探讨HDGF和VEGF在肝门部胆管癌中的表达与临床病理特征及预后的关系。然后研究其与临床病理特征的相关性。HDGF和VEGF阳性表达分别为27例（46.6%）和42例（72.4%）。斯皮尔曼等级相关分析显示HDGF与VEGF呈正相关（r = 0.370，P = 0.004）。HDGF表达与性别、组织学类型有关。HDGF阳性表达的患者的总生存率显著低于HDGF阴性表达的患者（35.7vs.73.3%，P = 0.003）。多因素分析显示HDGF表达是影响肝门部胆管癌预后的独立因素，HDGF表达与VEGF表达显著相关，是一个有价值的预后因素。
Overexpressions of hepatoma-derived growth factor (HDGF) and vascular endothelial growth factor (VEGF) play important roles in the development and progression of cancers. This study investigates the expression of HDGF combined with VEGF, their correlation with clinicopathologic features, and their prognosis in human hilar cholangiocarcinoma.The expressions of HDGF and VEGF were analyzed by immunohistochemistry using the streptavidin peroxidase complex method for 58 patients with hilar cholangiocarcinoma receiving surgery. Their correlation with clinicopathologic features was then investigated. The relationships between them and the survival time of patients were retrospectively analyzed.HDGF and VEGF were positively expressed in 27 (46.6%) and 42 (72.4%) patients, respectively. HDGF and VEGF had a positive correlation (r = 0.370, P = 0.004) in the Spearman rank correlation analysis. HDGF expression was associated with gender and histological type. Patients with positive HDGF expression had a significantly poorer overall survival rate than those with negative HDGF expression (35.7 vs. 73.3%, P = 0.003). Multivariate analysis showed that HDGF expression is an independent prognostic factor.HDGF expression significantly correlates with VEGF expression and is a valuable prognostic factor for human hilar cholangiocarcinoma.