Risk factors for the incidence of advanced age-related macular degeneration in the age-elated eye disease study (AREDS) - AREDS report no.19
Risk factors for the incidence of advanced age-related macular degeneration in the age-elated eye disease study (AREDS) - AREDS report no.19
复制标题
DOI：
10.1016/j.ophtha.2004.10.047
复制
发表时间：
2005-04-01
期刊：
影响因子：
13.7
通讯作者：
Sperduto, RD
中科院分区：
文献类型：
--
作者：
Milton, RC;Clemons, TE;Sperduto, RD
目的：在老年性黄斑变性相关眼病研究（AREDS）中描述人口统计学、行为学、医学和非视网膜眼部因素与新生血管性年龄相关性黄斑变性（AMD）和中央地图状萎缩（CGA）发病率的相关性。AREDS是一项抗氧化剂和锌补充预防晚期AMD发展的随机试验。设计：基于临床的前瞻性队列研究。参与者：在基线时患有早期或中期AMD的个体中，中位随访时间为6.3年，788例单眼有发展为晚期AMD的风险（对侧眼有晚期AMD），2506例双眼有风险。新生血管性AMD和CGA的发生率通过基线时和第2年开始的年度访视时拍摄的立体彩色眼底照片进行评估。新生血管性AMD定义为脉络膜新生血管的光凝，或在阅读中心的以下任何一项的照片记录：非玻璃状视网膜色素上皮脱离、浆液性或出血性视网膜脱离、视网膜或视网膜色素上皮下出血和视网膜下纤维化。中心地图状萎缩定义为地图状萎缩累及黄斑中心。结果：在多变量模型中，在双眼有晚期AMD风险的人群中，在控制年龄、性别和AREDS治疗组的同时，以下变量与新生血管性AMD的发病率在统计学上显著相关：种族（比值比[OR]，白色vs.黑人，6.77; 95%置信区间[CI]，1.24-36.9）和吸烟量较大（OR，> 10 vs. 10包-年vs.
Purpose: To describe the association of demographic, behavioral, medical, and nonretinal ocular factors with the incidence of neovascular age-related macular degeneration (AMD) and central geographic atrophy (CGA) in the Age-Related Eye Disease Study (AREDS), a randomized trial of antioxidants and zinc supplementation prophylaxis for development of advanced AMD.Design: Clinic-based prospective cohort study.Participants: Of individuals with early or intermediate AMD at baseline with a median follow-up of 6.3 years, 788 were at risk of developing advanced AMD in one eye (the fellow eye had advanced AMD), and 2506 were at risk in both eyes.Methods: The incidence of neovascular AMD and CGA was assessed from stereoscopic color fundus photographs taken at baseline and at annual visits beginning at year 2.Main Outcome Measures: Neovascular AMD was defined as photocoagulation for choroidal neovascularization, or photographic documentation at the reading center of any of the following: nondrusenoid retinal pigment epithelial detachment, serous or hemorrhagic retinal detachment, hemorrhage under the retina or the retinal pigment epithelium, and subretinal fibrosis. Central geographic atrophy was defined as geographic atrophy involving the center of the macula.Results: In multivariable models, in persons at risk of advanced AMD in both eyes, while controlling for age, gender, and AREDS treatment group, the following variables were statistically significantly associated with the incidence of neovascular AMD: race (odds ratio [OR], white vs. black, 6.77; 95% confidence interval [CI], 1.24-36.9) and larger amount smoked (OR, > 10 vs. 10 pack-years vs.