A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans
A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans
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DOI：
10.1210/jc.86.9.4552
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发表时间：
2001-09-01
影响因子：
5.8
通讯作者：
Nakao, K
中科院分区：
文献类型：
--
作者：
Hataya, Y;Akamizu, T;Nakao, K
GH 释放促泌素 (GHS) 和 GHRH 之间在 GH 分泌方面的协同关系是众所周知的。在本研究中，我们报告了 GHRH 和 ghrelin 之间的类似关系，ghrelin 是最近发现的 GHS 受体的内源性配体。在正常男性成人中，单独或与1.0μg/kg GHRH一起静脉注射不同剂量的ghrelin。在 0.08 和 0.2 mug/kg ghrelin 小剂量下，两种肽联合给药以协同方式显着刺激 GH 释放，两种肽组合的平均 GH 反应值大于单独每种肽的平均 GH 反应值之和（P
The synergistic relationship between GH-releasing secretagogue (GHS) and GH-releasing hormone (GHRH) with respect to GH secretion is well known, In the present study, we report a similar relationship between GHRH and ghrelin, a recently identified endogenous ligand for the GHS receptor. In normal male adults, various doses of ghrelin were intravenously administered alone or together with 1.0 mug/kg GHRH. At small doses of 0.08 and 0.2 mug/kg ghrelin, combined administration of the two peptides significantly stimulated GH release in a synergistic manner, the mean GH response values of the two peptide combinations were more than the summed mean GH response values of each peptide alone (P