Pathogenesis and Treatment of Facial Paralysis Due to Malignant External Otitis
Pathogenesis and Treatment of Facial Paralysis Due to Malignant External Otitis
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恶性外耳炎面瘫的发病机制及治疗
DOI：
10.1177/000348947208100505
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
J. R. Chandler
中科院分区：
文献类型：
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作者：
J. R. Chandler
1968年4月，我报告了13例起源于外耳道的严重坏死性感染。所有患者均患有糖尿病，所有病例中的致病微生物均为铜绿假单胞菌。6人面部麻痹，7人死亡。为了充分说明这种疾病的严重性及其预后不良，我提出了“恶性外耳炎"这个术语。此后，该系列报告的1例患者被发现患有鳞状细胞癌。这是在开颅手术过程中诊断出来的，该手术旨在切断V和IX颅神经，以缓解持续疼痛。癌被发现涉及整个后方的岩锥和V，VII和VIII颅神经。回想起来，这位特殊的病人似乎确实患有癌症，可能起源于外耳道区域，并通过面神经上升到颅中窝。即使在她去世之前，也没有癌症的局部证据。
In April, 1968, I reported a series of 13 patients with severe necrotizing infections which originated in the external auditory canal. All had diabetes and thc responsible organism in all instances was the Pseudomonas aeruginosa. Six had facial palsy and seven died. In order to indicate adequately the serious nature of this form of the disease and its poor prognosis, I proposed the term “malignant external otitis.”’ Since then one of the patients reported in that series was found to have squamous cell carcinoma. This was diagnosed during the course of a craniotomy which was pcrformed for the purpose of transecting the V and IX cranial nerves in order to relieve persistent pain. Carcinoma was found to involve the entire posterior aspect of the petrous pyramid and the V, VII and VIII cranial nerves. In retrospect, it appeared that this particular patient did indeed have carcinoma which presumably originated in the region of the external auditory canal and had ascended into the middle cranial fossa via the facial nerve. Even until the time of her death, there was no local evidence of carcinoma.