Time course of sympathetic neural hyperactivity after uncomplicated acute myocardial infarction
Time course of sympathetic neural hyperactivity after uncomplicated acute myocardial infarction
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DOI：
10.1161/01.cir.0000025610.14665.21
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发表时间：
2002-08-13
期刊：
影响因子：
37.8
通讯作者：
Mary, DASG
中科院分区：
文献类型：
--
作者：
Graham, LN;Smith, PA;Mary, DASG
背景-关于急性心肌梗死(AMI)后交感神经活动的信息很少，尽管人们认为交感神经活动与发病率和死亡率有关。间接指标，如血浆儿茶酚胺在无并发症的急性心肌梗死后一过性升高，而其他具有重要预后意义的自主神经指标可能受到较长时间的影响。我们计划量化无并发症急性心肌梗死后外周的中枢交感神经输出，并研究其随时间的进展。方法和结果--无并发症急性心肌梗死后，13例患者进行了多单位放电和具有明确血管收缩特性的单个单位的肌交感神经活动(S-肌交感神经活动评分)。于急性心肌梗死后2~4d进行检测，3个月和6个月后复查。我们还检查了3个匹配的对照组，包括正常受试者、冠状动脉疾病患者和非急性心肌梗死住院患者。急性心肌梗死后MSNA和S-MSNA(84+/-4.6次/100次和95+/-5.8次/100次)在3个月时无明显变化，但显著降低(P
Background-Little information is available on sympathetic activity after acute myocardial infarction (AMI), despite the belief that sympathetic drive is important in relation to morbidity and mortality. Indirect indices such as plasma catecholamines are transiently elevated after uncomplicated AMI, whereas other prognostically important autonomic indices may be affected longer. We planned to quantify central sympathetic output to the periphery after uncomplicated AMI and to investigate its progress over time.Methods and Results-After uncomplicated AMI, 13 patients had muscle sympathetic nerve activity (MSNA) assessed from multiunit discharges and from single units with defined vasoconstrictor properties (s-MSNA). Measurements were obtained 2 to 4 days after AMI and were repeated after 3 and 6 months. We also examined 3 matched control groups comprising normal subjects, patients with coronary artery disease, and hospitalized patients without AMI. MSNA and s-MSNA after AMI (84+/-4.6 bursts/100 beats and 95+/-5.8 impulses/100 beats) were unchanged at 3 months but decreased (P