A population-level decline in serum testosterone levels in American men
A population-level decline in serum testosterone levels in American men
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DOI：
10.1210/jc.2006-1375
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发表时间：
2007-01-01
影响因子：
5.8
通讯作者：
McKinlay, John B.
中科院分区：
文献类型：
--
作者：
Travison, Thomas G.;Araujo, Andre B.;McKinlay, John B.
内容：平均睾酮（T）浓度的年龄特异性估计值似乎因观察年份和出生队列而异，T的纵向下降估计值通常超过横截面下降。这些观察结果激发了一个假设，即在人口水平上T随日历时间的减少，与年龄无关。目的：本研究的目的是建立血清T浓度的人口水平变化的幅度，以及相对体重和其他因素的长期变化对它们的解释程度。设计：我们描述了一项随机选择的45 - 79岁男性的健康和内分泌功能的前瞻性队列研究。我们提供三种数据收集波：基线（T1：1987 - 1999）和两次随访（T2：1995 - 1997，T3：2002 - 2004）。设置：这是一项随机选择的居住在大波士顿，马萨诸塞州的男性的观察性研究。参与者：分别在T1、T2和T3时从1374、906和489名男性中获得数据，总计对1532名男性进行了2769次观察。主要结果指标：主要结果指标为血清总T和计算的生物可利用T。结果如下：我们观察到T的显著非年龄依赖性下降，这似乎不能归因于观察到的解释因素的变化，包括健康和生活方式特征，如吸烟和肥胖。估计的人口水平下降幅度大于横截面下降T通常与age.Conclusions：这些结果表明，近年来已经看到了大量的，但尚未认识到，年龄独立populationlevel下降T在美国男性，可能归因于出生队列差异或健康或环境影响没有捕获在观察到的数据。
Context: Age- specific estimates of mean testosterone ( T) concentrations appear to vary by year of observation and by birth cohort, and estimates of longitudinal declines in T typically outstrip cross-sectional decreases. These observations motivate a hypothesis of a populationlevel decrease in T over calendar time, independent of chronological aging.Objective: The goal of this study was to establish the magnitude of population-level changes in serum T concentrations and the degree to which they are explained by secular changes in relative weight and other factors.Design: We describe a prospective cohort study of health and endocrine functioning in randomly selected men of age 45 - 79 yr. We provide three data collection waves: baseline ( T1: 1987 - 1999) and two follow- ups ( T2: 1995 - 1997, T3: 2002 - 2004).Setting: This was an observational study of randomly selected men residing in greater Boston, Massachusetts.Participants: Data obtained from 1374, 906, and 489 men at T1, T2, and T3, respectively, totaling 2769 observations taken on 1532 men. Main Outcome Measures: The main outcome measures were serum total T and calculated bioavailable T. Results: We observe a substantial age- independent decline in T that does not appear to be attributable to observed changes in explanatory factors, including health and lifestyle characteristics such as smoking and obesity. The estimated population- level declines are greater in magnitude than the cross- sectional declines in T typically associated with age.Conclusions: These results indicate that recent years have seen a substantial, and as yet unrecognized, age- independent populationlevel decrease in T in American men, potentially attributable to birth cohort differences or to health or environmental effects not captured in observed data.