Patterns of adrenergic receptors and adrenergic agonists underlying cardiovascular responses to a psychological challenge.
Patterns of adrenergic receptors and adrenergic agonists underlying cardiovascular responses to a psychological challenge.
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肾上腺素能受体和肾上腺素能激动剂的模式是心血管对心理挑战的反应的基础。
DOI：
10.1097/00006842-199401000-00009
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发表时间：
1994
影响因子：
3.3
通讯作者：
Kennedy,B
中科院分区：
文献类型：
--
作者：
Mills,PJ;Dimsdale,JE;Nelesen,RA;Jasiewicz,J;Ziegler,MG;Kennedy,B
许多生理生化因素参与心血管系统的动态调节。本研究使用聚类分析统计技术来辨别肾上腺素能受体和肾上腺素能激动剂对实验室挑战的心血管反应的模式。50例高血压和正常血压的黑人和白人通过注射激动剂测定了他们的-和-肾上腺素能受体敏感性。对标准化心算任务的去甲肾上腺素、肾上腺素、血压和心率的反应也得到了。聚类分析确定了四个亚组个体具有不同的受体和神经激素调节终器官反应的模式。总的来说，数据表明终器官心血管反应部分是由肾上腺素能受体的敏感性和伴随的儿茶酚胺反应决定的。研究结果还表明，对于某些个体，非肾上腺素能因素在决定心血管压力反应方面比肾上腺素能机制发挥更大的作用。
: Numerous physiological and biochemical factors contribute to the dynamic regulation of the cardiovascular system. This study used a cluster analytic statistical technique to discern patterns of adrenergic receptors and adrenergic agonists underlying cardiovascular responses to a laboratory challenge. Fifty hypertensive and normotensive black and white individuals had their beta-and alpha-adrenergic receptor sensitivity determined through agonist infusions. Norepinephrine, epinephrine, blood pressure, and heart rate responses to a standardized mental arithmetic task were also obtained. The cluster analysis identified four subgroups of individuals having distinct patterns of receptor and neurohormonal regulation of end-organ responses. In general, the data indicated that end-organ cardiovascular responses are, in part determined by the sensitivity of adrenergic receptors and the accompanying catecholamine responses. The findings also suggest that for some individuals nonadrenergic factors play a more dominant role than adrenergic mechanisms in determining cardiovascular pressor responses.