Molecular genetics of supernumerary tooth formation.
Molecular genetics of supernumerary tooth formation.
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DOI：
10.1002/dvg.20715
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发表时间：
2011-04
期刊：
影响因子：
1.5
通讯作者：
Fan, Jiabing
中科院分区：
文献类型：
--
作者：
Wang, Xiu-Ping;Fan, Jiabing
关键词：
尽管对牙齿形态发生和分化的了解有所进展，但对多生牙齿形成的病因和分子机制知之甚少。少量的多生牙齿可能是一种常见的发育性牙齿异常，而多生牙齿通常具有遗传成分，有时被认为代表了人类部分的第三齿。通常用于研究牙齿发育的小鼠只显示出一颗牙列，很少有小鼠模型显示出与人类相似的多余牙齿。Apc失活或Wnt/β catenin信号的强制激活导致人类和小鼠多牙形成，但这些途径的关键基因尚不清楚。对鱼类、蛇、蜥蜴和雪貂等具有连续牙齿替换或继发牙齿形成的其他模型系统的分析，有助于深入了解连续牙齿发育的分子和细胞机制，并有助于研究人类多余牙齿的形成。这一研究成果，再加上干细胞生物学和组织工程学的进展，将为牙齿再生和牙齿生物工程的发展铺平道路。
Despite advances in the knowledge of tooth morphogenesis and differentiation, relatively little is known about the aetiology and molecular mechanisms underlying supernumerary tooth formation. A small number of supernumerary teeth may be a common developmental dental anomaly, while multiple supernumerary teeth usually have a genetic component and they are sometimes thought to represent a partial third dentition in humans. Mice, which are commonly used for studying tooth development, only exhibit one dentition, with very few mouse models exhibiting supernumerary teeth similar to those in humans. Inactivation of Apc or forced activation of Wnt/β(catenin signalling results in multiple supernumerary tooth formation in both humans and in mice, but the key genes in these pathways are not very clear. Analysis of other model systems with continuous tooth replacement or secondary tooth formation, such as fish, snake, lizard, and ferret, is providing insights into the molecular and cellular mechanisms underlying succesional tooth development, and will assist in the studies on supernumerary tooth formation in humans. This information, together with the advances in stem cell biology and tissue engineering, will pave ways for the tooth regeneration and tooth bioengineering.
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影响因子：
168.9
作者：
CASPARI, R;FRIEDL, W;PROPPING, P
通讯作者：
PROPPING, P
DOI：
10.1016/0002-9416(82)90080-x
发表时间：
1982-01-01
影响因子：
3
作者：
BECKER, A;BIMSTEIN, E;SHTEYER, A
通讯作者：
SHTEYER, A
影响因子：
4.6
作者：
Ahn, Youngwook;Sanderson, Brian W.;Krumlauf, Robb
通讯作者：
Krumlauf, Robb
影响因子：
--
作者：
BERKOVITZ, BKB;MOORE, MH
通讯作者：
MOORE, MH
影响因子：
3.3
作者：
Batra, P;Duggal, R;Parkash, H
通讯作者：
Parkash, H