A neurocognitive model for understanding treatment action in depression
A neurocognitive model for understanding treatment action in depression
复制标题
用于理解抑郁症治疗行动的神经认知模型
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
C. Harmer
中科院分区：
文献类型：
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作者：
M. Warren;A. Pringle;C. Harmer
情绪在人脑中的表现和处理方式是一个不断扩展的研究领域，对我们如何理解和潜在治疗抑郁症等情感障碍具有关键影响。描述关键神经递质系统的药理学操作的影响也可以帮助揭示情绪处理的神经化学基础，以及常见的抗抑郁药物如何治疗抑郁症和焦虑症。这种方法揭示了抑郁症与神经和行为对消极刺激的偏见有关。来自药理学挑战研究的证据表明，抗抑郁药治疗可以在治疗早期使这些偏见正常化，从而使患者以更积极的方式体验世界，随着时间的推移改善他们的情绪。这一模型得到了药理学和非药理学干预证据的支持。这种方法提供的抗抑郁治疗的独特视角提供了一些见解，个人对治疗的反应，以及药物开发的新方法。
The way in which emotion is represented and processed in the human brain is an expanding area of research and has key implications for how we understand and potentially treat affective disorders such as depression. Characterizing the effects of pharmacological manipulations of key neurotransmitter systems can also help reveal the neurochemical underpinnings of emotional processing and how common antidepressant drugs may work in the treatment of depression and anxiety. This approach has revealed that depression is associated with both neural and behavioural biases towards negative over positive stimuli. Evidence from pharmacological challenge studies suggests that antidepressant treatment acts to normalize these biases early on in treatment, resulting in patients experiencing the world in a more positive way, improving their mood over time. This model is supported by evidence from both pharmacological and non-pharmacological interventions. The unique perspective on antidepressant treatment offered by this approach provides some insights into individual response to treatment, as well as novel approaches to drug development.
重度抑郁症首次发作的病前人格评估。
影响因子：
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作者：
Hirschfeld,RM;Klerman,GL;Lavori,P;Keller,MB;Griffith,P;Coryell,W
通讯作者：
Coryell,W