Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effects
Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effects
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DOI：
10.1002/smll.200700670
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发表时间：
2008-02-01
期刊：
影响因子：
13.3
通讯作者：
Saito, Naoto
中科院分区：
文献类型：
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作者：
Usui, Yuki;Aoki, Kaoru;Saito, Naoto
碳纳米管（CNTs）作为与其他物质的复合材料或单独用于开发高功能材料已被应用于各个领域。CNT对于生物材料，特别是那些与骨接触的生物材料，例如用于关节成形术的假体、用于骨折固定的板或螺钉、药物递送系统和用于骨再生的支架，具有很大的兴趣。因此，碳纳米管的骨组织相容性和碳纳米管对骨形成的影响是重要的问题，但碳纳米管对骨的影响还没有被描绘出来。在这里，人们发现，多壁碳纳米管毗邻骨诱导很少的局部炎症反应，显示出高骨组织相容性，允许骨修复，成为整合到新骨，并加速骨形成的刺激重组人骨形态发生蛋白-2（rhBMP-2）。这项研究为用于骨附近的生物材料中的CNT提供了初步的研究基础，包括用于促进骨再生。这些发现应该鼓励涉及碳纳米管的临床治疗方式的发展。
Carbon nanotubes (CNTs) have been used in various fields as composites with other substances or alone to develop highly functional materials. CNTs hold great interest with respect to biomaterials, particularly those to be positioned in contact with bone such as prostheses for arthroplasty, plates or screws for fracture fixation, drug delivery systems, and scaffolding for bone regeneration. Accordingly, bone-tissue compatibility of CNTs and CNT influence on bone formation are important issues, but the effects of CNTs on bone have not been delineated. Here, it is found that multi-walled CNTs adjoining bone induce little local inflammatory reaction, show high bone-tissue compatibility, permit bone repair, become integrated into new bone, and accelerate bone formation stimulated by recombinant human bone morphogenetic protein-2 (rhBMP-2). This study provides an initial investigational basis for CNTs in biomaterials that are used adjacent to bone, including uses to promote bone regeneration. These findings should encourage development of clinical treatment modalities involving CNTs.