High-performance 3D printing of hydrogels by water-dispersible photoinitiator nanoparticles.
High-performance 3D printing of hydrogels by water-dispersible photoinitiator nanoparticles.
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DOI：
10.1126/sciadv.1501381
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发表时间：
2016-04
期刊：
影响因子：
13.6
通讯作者：
Magdassi S
中科院分区：
文献类型：
--
作者：
Pawar AA;Saada G;Cooperstein I;Larush L;Jackman JA;Tabaei SR;Cho NJ;Magdassi S
光引发剂纳米颗粒能够使用数码光打印机快速3D打印水性系统中的水凝胶。在不存在在紫外（UV）-可见光范围内具有高吸光度的水溶性光引发剂的情况下，用于组织工程的水凝胶的快速三维（3D）打印是具有挑战性的。一种新的方法，使水凝胶在水溶液中的快速3D打印的基础上，紫外线固化油墨含有高效，但水不溶性的光引发剂的纳米粒子。2，4，6-三甲基苯甲酰基-二苯基氧化膦（TPO）的新型水分散性纳米颗粒的消光系数比最好和最常用的市售水溶性光引发剂大300倍以上。TPO纳米颗粒在385至420 nm范围内吸收显著，使其适用于使用数字光处理的市售低成本发光二极管3D打印机。在这个范围内的聚合速率非常快，并且能够实现3D打印，否则在不添加溶剂的情况下不可能进行3D打印。TPO纳米粒子通过挥发性微乳液快速转化为水分散性粉末来制备，该方法可用于各种光引发剂。这种水分散性光引发剂纳米颗粒提供了许多机会，使在水溶液中制备的结构能够快速3D打印，同时通过使用低能量固化体系并避免对溶剂的需求而带来环境优势。
Photoinitiator nanoparticles enable rapid 3D printing of hydrogels from waterborne systems using digital light printers. In the absence of water-soluble photoinitiators with high absorbance in the ultraviolet (UV)–visible range, rapid three-dimensional (3D) printing of hydrogels for tissue engineering is challenging. A new approach enabling rapid 3D printing of hydrogels in aqueous solutions is presented on the basis of UV-curable inks containing nanoparticles of highly efficient but water-insoluble photoinitiators. The extinction coefficient of the new water-dispersible nanoparticles of 2,4,6-trimethylbenzoyl-diphenylphosphine oxide (TPO) is more than 300 times larger than the best and most used commercially available water-soluble photoinitiator. The TPO nanoparticles absorb significantly in the range from 385 to 420 nm, making them suitable for use in commercially available, low-cost, light-emitting diode–based 3D printers using digital light processing. The polymerization rate at this range is very fast and enables 3D printing that otherwise is impossible to perform without adding solvents. The TPO nanoparticles were prepared by rapid conversion of volatile microemulsions into water-dispersible powder, a process that can be used for a variety of photoinitiators. Such water-dispersible photoinitiator nanoparticles open many opportunities to enable rapid 3D printing of structures prepared in aqueous solutions while bringing environmental advantages by using low-energy curing systems and avoiding the need for solvents.