Postnatal remodeling of the laryngeal airway removes body size dependency of spectral features for ultrasonic whistling in laboratory mice
Postnatal remodeling of the laryngeal airway removes body size dependency of spectral features for ultrasonic whistling in laboratory mice
复制标题
DOI：
10.1111/jzo.13003
复制
发表时间：
2022-07-18
影响因子：
2
通讯作者：
Riede, T.
中科院分区：
文献类型：
--
作者：
Darwaiz, T.;Pasch, B.;Riede, T.
在许多哺乳动物中，声信号的光谱特性与物种内和物种间的体型成正比。然而，在啮齿类动物中，尽管体型发生了巨大的变化，但从出生到成年，用于社会交流的超声波哨声的基本频率（F0）范围保持相对一致。这种不同的模式可能是由于啮齿类动物特有的一种新的声音产生机制，涉及被称为腹侧袋的咽内中线袋。在本研究中，我们通过个体发育分析了CD1小鼠出生后喉道的形状和大小，以更好地了解腹侧小袋几何形状与超声哨子F0之间的关系。腹侧袋体积（0.06±0.01 mm(3)）在幼犬和1岁成年犬之间没有差异，尽管喉内肌肉组织和结缔组织存在广泛的形状诱导重塑。相比之下，2岁小鼠的腹侧袋体积比1岁小鼠小50%。因此，喉道的异速分布似乎解释了年轻的小老鼠和年老的大老鼠的超声哨声之间的频谱重叠。在老年小鼠中，发声行为的减少和腹侧囊的收缩之间的因果关系尚不清楚。总之，这些数据使我们了解小家鼠出生后的发育和喉内气道的重塑。
In many mammals, spectral properties of acoustic signals scale with body size within and among species. In rodents, however, despite drastic changes in body size, fundamental frequency (F0) range of ultrasonic whistles produced for social communication remain relatively uniform from birth to adulthood. Such divergent patterns may be due to a novel sound production mechanism unique to rodents involving an intralaryngeal midline pocket termed the ventral pouch. In this study, we analyzed the postnatal shape and size of the laryngeal airway in CD1 mice over ontogeny to better understand the association between ventral pouch geometry and F0 of ultrasonic whistles. Ventral pouch volume (0.06 +/- 0.01 mm(3)) did not differ between pups and 1-year-old adults despite extensive shape-inducing remodeling of the intralaryngeal musculature and connective tissue. In contrast, ventral pouch volume was 50% less in 2-year-old compared to 1-year-old mice. Thus, allometry of the laryngeal airway appears to explain spectral overlap between ultrasonic whistles of young, small mice and older, larger mice. The causal association between the reduction in vocal behavior and a seemingly shrinking ventral pouch in geriatric mice remains unclear. Together, these data inform our understanding of the postnatal development and remodeling of the intralaryngeal airway in Mus musculus.