Treatment of cytomegaloviral pneumonia with high-dose acyclovir and human leukocyte interferon.
Treatment of cytomegaloviral pneumonia with high-dose acyclovir and human leukocyte interferon.
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用大剂量阿昔洛韦和人白细胞干扰素治疗巨细胞病毒性肺炎。
DOI：
10.1093/infdis/148.3.557
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Meyers,JD
中科院分区：
文献类型：
--
作者：
Wade,JC;McGuffin,RW;Springmeyer,SC;Newton,B;Singer,JW;Meyers,JD
13 名骨髓移植受者接受了高剂量阿昔洛韦和 α-干扰素（Cantell 干扰素）治疗经活检证实的巨细胞病毒性肺炎。三名患者幸存。阿昔洛韦剂量为 500 至 1,000 mg/m2 体表面积（峰值血浆水平，7-86 μg/ml），干扰素剂量为每天 2 × 104 至 40 × 104 单位/kg（峰值血清水平，5-608 单位/ml）。尽管使用了大剂量，但没有观察到一致的抗病毒效果。 5 名患者出现了与该方案相关的可能的骨髓毒性，2 名患者出现了神经系统症状，1 名患者出现了肾毒性。因此，大剂量阿昔洛韦加α-干扰素治疗具有中等毒性，但对骨髓移植后的巨细胞病毒肺炎无效。
Thirteen recipients of bone marrow transplants were given high-dose acyclovir and α-interferon (Cantell interferon) for the treatment of biopsy-proven cytomegaloviral pneumonia. Three patients survived. Doses of acyclovir between 500 and 1,000 mg/m2of body surface area (peak plasma levels, 7–86 μg/ml) and doses of interferon between 2 × 104and 40 × 104units/kg per day (peak serum levels, 5–608 units/ml) were given. No consistent antiviral effect was seen despite the large doses employed. Possible marrow toxicity associated with this regimen occurred in five patients, neurologic symptoms in two, and nephrotoxicity in one. Thus, treatment with high-dose acyclovir plus a-interferon was moderately toxic but ineffective against cytomegaloviral pneumonia after bone marrow transplantation.